1st Optimal vs Magnolia Regenerative Medicine
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Magnolia Regenerative Medicine
Best for: readers who want a published state list and a low compounded semaglutide entry price
Visit Magnolia Regenerative Medicine →1st Optimal and Magnolia Regenerative Medicine are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both start around $99/mo, and Magnolia Regenerative Medicine edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Magnolia Regenerative Medicine
Published as "from $99/mo."; the per-dose ladder appears only after intake.
Published as "from $179/mo."; the per-dose ladder appears only after intake.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Magnolia Regenerative Medicine
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Not disclosed
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Magnolia Regenerative Medicine
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Magnolia Regenerative Medicine |
|---|---|---|
| Starting Price | $99/mo | $99/mo |
| Features | ✓8 features | 5 features |
| States Available | Not disclosed | 26 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Magnolia Regenerative Medicine
Magnolia Regenerative Medicine is a Louisiana-based telehealth and clinic practice selling compounded GLP-1s alongside hormone, recovery and cognitive programs. Semaglutide+B12 starts at $99/mo and Tirzepatide+B12 at $179/mo, both offered on monthly or quarterly plans. It is one of the few compounded sellers that publishes its full telehealth state list rather than hiding it behind an intake form, and it also runs two brick-and-mortar clinics for in-person visits.
Read our full Magnolia Regenerative Medicine review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Magnolia Regenerative Medicine
What we like
- Publishes its full telehealth state list — 26 states plus D.C. — instead of gating it behind an intake form.
- Semaglutide+B12 starts at $99/mo, at the low end of the compounded market.
- Tirzepatide+B12 starts at $179/mo, with monthly and quarterly plan options.
- Publishes a LegitScript seal ID that resolves against LegitScript's CDN, though the badge itself links only to a generic lookup.
- Two Louisiana clinics offer in-person visits alongside the telehealth service.
- Publishes a support phone number and email address directly on every page.
Watch-outs
- The per-dose price ladder appears only after you supply a name and email; the public pages show "from" figures only.
- No compounding pharmacy is named — the site says only "highly accredited, top-tier compounding pharmacies".
- Lab work is billed separately: $89 for the Essential panel, $189 for the Comprehensive panel.
- A strict no-refund policy applies, and the terms state there are no refunds on medications.
- Canceling requires written notice at least 24 hours before the monthly renewal.
- An "As seen in" row shows Bloomberg, Fox Business and NASDAQ logos, none of which link to any coverage.
- A 4.9/5 star rating is displayed with no named review source behind it.
- Louisiana is not on the telehealth list, so in-state readers must use a clinic in person.
Our Verdict
Magnolia Regenerative Medicine edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for readers who want a published state list and a low compounded semaglutide entry price. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Magnolia Regenerative Medicine if…
You want readers who want a published state list and a low compounded semaglutide entry price and a starting price around $99/mo.
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YourEra
$99 first-month entry pricing on compounded GLP-1s
From $149/mo
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Compounded GLP-1/GIP combo on a yearly plan with free shipping
From $149/mo
Get started →TMates
Nationwide compounded GLP-1 availability including Puerto Rico
From $249/mo
Get started →1st Optimal vs Magnolia Regenerative Medicine: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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