1st Optimal vs MadeMed
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
1st Optimal and MadeMed are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, MadeMed starts at $219/mo, and MadeMed edges ahead overall (7.4 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
MadeMed
Quarterly plan $239/mo (billed $717/3mo); 6-month plan drops to $199/mo (the site's 'From $199/mo'). Includes L-Carnitine; 2-month supplies.
Quarterly $399/mo (billed $1,197/3mo); 6-month $369/mo.
Quarterly $219/mo (billed $657/3mo); 6-month $179/mo. Includes B6.
Quarterly $299/mo (billed $897/3mo); 6-month $279/mo.
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Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
MadeMed
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | MadeMed |
|---|---|---|
| Starting Price | — | $219/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About MadeMed
MadeMed is a direct-to-consumer GLP-1 telehealth platform offering compounded semaglutide and tirzepatide in both injectable and oral forms — four distinct products, giving needle-averse patients more choice than most competitors. It displays a LegitScript certification badge and publishes a customer support line, uncommon among chat-only rivals. Pricing is gated behind the product or checkout flow rather than shown publicly.
Read our full MadeMed review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
MadeMed
What we like
- Four products — injectable and oral semaglutide and tirzepatide — giving needle-averse patients more options
- LegitScript certification badge on the homepage
- Customer phone support published (1-800-582-1428) — uncommon vs chat-only competitors
- Affiliate partnership available via the Katalys network
Watch-outs
- Pricing not shown publicly — gated behind product pages or checkout
- Pharmacy partner not named
- States served not disclosed
- No named medical director or clinical leadership
- 503A vs 503B compounding designation not specified
- Corporate legal entity not disclosed
- FDA compounded-medication disclaimer not visible in the page HTML
- Governing law and arbitration venue not disclosed
Our Verdict
MadeMed edges out 1st Optimal with a higher overall score of 7.4/10 and is particularly strong for compounded GLP-1 in both injection and oral forms. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose MadeMed if…
You want compounded GLP-1 in both injection and oral forms and a starting price around $219/mo.
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Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Breeze Meds
Compounded GLP-1 access with named prescribers and 4-pharmacy network
From $169/mo
Get started →Telos Rx
Needle-free and microdosed compounded GLP-1 options with lab-monitored care
From $49/mo
Get started →1st Optimal vs MadeMed: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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