1st Optimal vs LunaRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
LunaRx
Best for: adults who want a GLP-1 program with muscle-protective peptides and a built-in off-ramp taper
Visit LunaRx →1st Optimal and LunaRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, LunaRx starts at $199/mo, and LunaRx edges ahead overall (7.2 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
LunaRx
Published headline is "from $199/mo" for the entry Foundation stack (compounded semaglutide + muscle-protective peptides). Specific tier and tirzepatide pricing are confirmed only after a provider review; no per-dose price list is published.
What’s included
1st Optimal
Inclusions not disclosed.
LunaRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
LunaRx
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | LunaRx |
|---|---|---|
| Starting Price | — | $199/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About LunaRx
LunaRx is a bilingual (English/Spanish) telehealth practice from LunaRx LLC built around "metabolic recomposition" — compounded GLP-1 therapy paired with muscle-protective peptides and a structured off-ramp taper, rather than an indefinite prescription. Programs start at $199/month; specific tier and tirzepatide pricing are confirmed only after a physician review. Care is physician-directed through an independent medical group (CareNexus Clinic PC), with $0 charged if you are not approved. Compounded medications are not FDA-approved.
Read our full LunaRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
LunaRx
What we like
- Pairs GLP-1 with muscle-protective peptides (e.g., CJC-1295/Ipamorelin, NAD+) to defend lean mass during fat loss
- Structured, physician-directed off-ramp taper with GI-reset support instead of an indefinite prescription
- Bilingual care in English and Spanish across intake, messaging, and consults
- Care directed through a named independent medical group (CareNexus Clinic PC); $0 charged if you are not approved
- Published clinical support hours (Mon–Fri, CT) with phone, email, and secure messaging; cancel anytime
- 503A compounded medications prepared in the USA and shipped discreetly to your door
Watch-outs
- Only a "from $199/mo" starting price is published; tirzepatide and per-tier pricing are confirmed only after a provider review
- Compounding pharmacy partners are not named on the site — a transparency gap
- No LegitScript or PCAB verification is displayed
- States served are not published; the site claims "telehealth nationwide" but the Terms limit service to states where LunaRx is licensed
- Compounded medications are not FDA-approved (the site discloses this)
- No refunds once medication is dispensed; order cancellations are only accepted within 24 hours
- New brand with no independent Trustpilot or third-party rating; on-site testimonials only
Our Verdict
LunaRx edges out 1st Optimal with a higher overall score of 7.2/10 and is particularly strong for adults who want a GLP-1 program with muscle-protective peptides and a built-in off-ramp taper. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose LunaRx if…
You want adults who want a GLP-1 program with muscle-protective peptides and a built-in off-ramp taper and a starting price around $199/mo.
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Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $49/mo
Get started →Embody
Lowest first-month entry pricing on compounded GLP-1s
From $99/mo
Get started →TrimRx
Best overall value
From $179/mo
Get started →1st Optimal vs LunaRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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