1st Optimal vs Loozy
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Loozy
Best for: people who want semaglutide or tirzepatide on a 3-month plan from a brand that names its doctors and pharmacy
Visit Loozy →1st Optimal and Loozy are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $149/mo, and 1st Optimal edges ahead overall (6.7 vs 6.6 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Loozy
Homepage: "$199/mo, billed as a 3-month plan." Membership includes the consult.
The next 3-month block after Starter costs $657.
Listed in the intake plan menu as "$447 for 3 months." Fixed low dose.
Tirzepatide pricing appears only inside the intake, not on the homepage.
$998 per 3 months, about $332.67/mo.
$1,110 per 3 months.
Listed in the intake plan menu as "$647 for 3 months," about $215.67/mo.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Loozy
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Billed separately
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Loozy
6.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Loozy |
|---|---|---|
| Starting Price | ✓$99/mo | $149/mo |
| Features | ✓8 features | 7 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Loozy
Loozy is a casual-toned telehealth brand selling compounded semaglutide and tirzepatide as a 3-month membership paid upfront, with prescribing by Elite Care Health and fulfillment by Rx Ave Health. Semaglutide starts at $199/mo ($597 per 3 months) and tirzepatide at $249/mo ($747); lower-cost microdosing plans exist, and the price rises when you move to higher doses.
Read our full Loozy review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Loozy
What we like
- Names its medical group (Elite Care Health) and its pharmacy (Rx Ave Health), which many brands never disclose
- Semaglutide starts at $199/mo on a 3-month plan, with a $149/mo microdosing option
- Membership covers the provider review, dose titration, medication and unlimited async messaging
- Full refund if you cancel before a provider reviews your intake; $59 kept if you are not approved
- Cash-pay with HSA/FSA use suggested, so no insurance paperwork
- Offers both compounded semaglutide and tirzepatide, plus low-dose microdosing plans
Watch-outs
- No month-to-month option: every plan is a 3-month membership charged in full upfront
- Price rises as you move up in dose: semaglutide goes from $597 to $657 per 3 months, tirzepatide from $747 to $1,110
- Tirzepatide prices are not on the homepage; you only see them inside the intake
- You must give your name, email and phone before seeing plans, and throwaway emails are rejected
- Membership fees are non-refundable once a provider has reviewed your intake, apart from the partial refunds in the policy
- Homepage testimonials are labeled "illustrative composites," not real patient reviews
- State coverage is described three different ways and no state list is published
- Support is email-only; no phone number is published
Our Verdict
1st Optimal edges out Loozy with a higher overall score of 6.7/10 and is particularly strong for GLP-1 therapy within a lab-driven functional-medicine program. Loozy remains a solid alternative, especially if you're looking for people who want semaglutide or tirzepatide on a 3-month plan from a brand that names its doctors and pharmacy.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Loozy if…
You want people who want semaglutide or tirzepatide on a 3-month plan from a brand that names its doctors and pharmacy and a starting price around $149/mo.
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Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →Sesame Care
Brand-name GLP-1s at cash prices, no compounding
From $25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
From $59/mo
Get started →1st Optimal vs Loozy: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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