1st Optimal vs Longevixx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Longevixx
Best for: one flat price at every dose across four GLP-1 formats, with a dietitian visit included
Visit Longevixx →1st Optimal and Longevixx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Longevixx starts at $129/mo, and Longevixx edges ahead overall (7.4 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Longevixx
Cheapest program on the post-eligibility menu; the site does not name which GLP-1 molecule the microdose uses.
Shown as $149 against a struck-through $199; the basis of the $199 is not stated on the menu.
Oral option on the same menu; the site does not name the molecule.
Labelled Most Chosen on the treatment menu.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Longevixx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Longevixx
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Longevixx |
|---|---|---|
| Starting Price | — | $129/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Longevixx
Longevixx is a physician-led longevity practice run by Longevixx LLC out of Charlotte, North Carolina, offering compounded semaglutide, compounded tirzepatide, a GLP-1 microdose protocol and a daily oral GLP-1 alongside a deep peptide menu. One price covers every dosage, so titrating up does not raise the bill, and the plan bundles medication, physician review, care coaching and a dietitian visit. Prices are published, but only after you finish the eligibility questionnaire: $149 semaglutide, $299 tirzepatide, $129 microdose, $229 oral.
Read our full Longevixx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Longevixx
What we like
- One price covers every dosage, so titrating up to a therapeutic dose does not raise your monthly bill
- The plan bundles medication, board-certified physician review, care coaching and a free dietitian visit
- Four GLP-1 formats including a lower-dose microdose protocol at $129 and a daily oral option at $229
- You are not charged unless a provider approves treatment, and shipping is free and discreet
- Unusually deep peptide menu alongside the GLP-1 programs, with each price listed
Watch-outs
- No price appears anywhere on the public site; you must finish the eligibility questionnaire to see the menu
- Semaglutide is shown as $149 against a struck-through $199 with no explanation of what the $199 refers to
- Tirzepatide at $299 is well above the market median, and it is the option flagged Most Chosen
- No compounding pharmacy is named; the site refers only to state-licensed compounding pharmacies
- A 4.8/5 star rating is displayed on the funnel with no source or review platform behind it
- Terms state you are charged immediately and every 30 days thereafter until you cancel
Our Verdict
Longevixx edges out 1st Optimal with a higher overall score of 7.4/10 and is particularly strong for one flat price at every dose across four GLP-1 formats, with a dietitian visit included. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Longevixx if…
You want one flat price at every dose across four GLP-1 formats, with a dietitian visit included and a starting price around $129/mo.
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Get started →1st Optimal vs Longevixx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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