1st Optimal vs Liberty
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Liberty
Best for: people who want nationwide compounded semaglutide or tirzepatide from 503B-sourced pharmacies
Visit Liberty →1st Optimal and Liberty are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Liberty starts at $199/mo, and Liberty edges ahead overall (7.7 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Liberty
Compounded semaglutide weekly injection, flat $199/mo; drops to about $171/mo on a 3-month supply. Sourced from a 503B outsourcing facility; Rx after clinician review.
Compounded tirzepatide (dual GIP/GLP-1) weekly injection, flat $299/mo. Sourced from a 503B outsourcing facility; Rx after clinician review.
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 420+ providers' prices on their own sites and email you when tracked prices move.
What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Liberty
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Liberty
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Liberty |
|---|---|---|
| Starting Price | — | $199/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Liberty
Liberty (Liberty Health) is a nationwide online weight-loss and wellness service offering compounded GLP-1 sourced from FDA-registered 503B outsourcing facilities. After a quiz and licensed-provider review, it prescribes compounded semaglutide injection at $199/month (about $171/month on a 3-month supply) and compounded tirzepatide injection at $299/month, marketed as up to 85% less than brand-name. It serves all 50 states with free shipping, 24/7 support, and FSA/HSA acceptance, and also offers microdosing, NAD+, sermorelin, and metformin. It does not name its specific pharmacy partner.
Read our full Liberty review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Liberty
What we like
- Compounded GLP-1 sourced from FDA-registered 503B outsourcing facilities, a stricter standard than the 503A pharmacies many competitors use
- Transparent flat pricing: compounded semaglutide $199/mo (about $171/mo on a 3-month supply) and tirzepatide $299/mo
- Nationwide in all 50 states with free discreet shipping, 24/7 support, and FSA/HSA acceptance
- Multi-vertical menu beyond weight loss (low-dose microdosing, NAD+, sermorelin, metformin) for patients who want bundled wellness care
Watch-outs
- Does not name its specific compounding pharmacy partner, only that it is a 503B facility
- Tirzepatide at $299/mo is mid-market rather than the cheapest option among compounded providers
- Generic corporate branding (Liberty Health) with limited public detail on the operating entity
- Compounded medication only — no brand-name or insurance-covered GLP-1 path
Our Verdict
Liberty edges out 1st Optimal with a higher overall score of 7.7/10 and is particularly strong for people who want nationwide compounded semaglutide or tirzepatide from 503B-sourced pharmacies. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Liberty if…
You want people who want nationwide compounded semaglutide or tirzepatide from 503B-sourced pharmacies and a starting price around $199/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →RxSpan MD
Shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →1st Optimal vs Liberty: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and Liberty head-to-heads in the same category.
- 1st Optimal vs Amazon One Medical
- 1st Optimal vs Vytora Health
- 1st Optimal vs CoreAge Rx
- Liberty vs EverSlim
- Liberty vs Found
- Liberty vs NewSelf
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.