1st Optimal vs LevelUp Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
LevelUp Rx
Best for: compounded GLP-1 at a flat price with named pharmacies
Visit LevelUp Rx →1st Optimal and LevelUp Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $149.97/mo, and LevelUp Rx edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
LevelUp Rx
1-month plan. 6 months is $809.95 and 12 months $1,349.97.
1-month $249.97/mo; 6-month $1349.82; 12-month $2349.88. Flat across all doses.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
LevelUp Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
LevelUp Rx
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | LevelUp Rx |
|---|---|---|
| Starting Price | ✓$99/mo | $149.97/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About LevelUp Rx
LevelUp Rx is a telehealth pharmacy offering compounded GLP-1 weight-loss medications - compounded semaglutide and compounded tirzepatide - alongside a broad menu of men's and women's health treatments. A no-cost online consultation is reviewed by US board-certified physicians, and approved prescriptions ship free from accredited partner pharmacies. Compounded semaglutide starts at $149.97/mo and tirzepatide at $249.97/mo, one flat price regardless of dose.
Read our full LevelUp Rx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
LevelUp Rx
What we like
- Compounded semaglutide ($149.97/mo) and tirzepatide ($249.97/mo) on one platform
- Flat monthly price that never changes with your dose
- No-cost online consultation included with your order
- LegitScript-certified; partner pharmacies named (DiRx and The DrugStore)
- Free shipping with no insurance required
- Published patient-care phone line and email support
Watch-outs
- Compounded only - no brand-name Wegovy, Zepbound, Ozempic or Mounjaro
- No single prescribing medical group named; physicians listed only for CA, MA, RI and VT
- State availability is confirmed during intake, not published as a list
- Prescription sales are final once shipped; no returns on dispensed medication
Our Verdict
LevelUp Rx edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for compounded GLP-1 at a flat price with named pharmacies. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose LevelUp Rx if…
You want compounded GLP-1 at a flat price with named pharmacies and a starting price around $149.97/mo.
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Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →ShedRx
Mainstream telehealth GLP-1 access
From $149/mo
Get started →bmiMD
Mainstream telehealth GLP-1 access
From $99/mo
Get started →1st Optimal vs LevelUp Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.