1st Optimal vs LevelUp Rx
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
LevelUp Rx
Best for: compounded semaglutide and tirzepatide at a flat price with named pharmacies
Visit LevelUp Rx →1st Optimal and LevelUp Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, LevelUp Rx starts at $149.97/mo, and LevelUp Rx edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
LevelUp Rx
1-month $149.97/mo; 6-month $809.95; 12-month $1349.97. Verified leveluprx.com/product/glp-1-medications 2026-06-19. Flat across all doses.
1-month $249.97/mo; 6-month $1349.82; 12-month $2349.88. Verified leveluprx.com 2026-06-19. Flat across all doses.
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 420+ providers' prices on their own sites and email you when tracked prices move.
What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
LevelUp Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
LevelUp Rx
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | LevelUp Rx |
|---|---|---|
| Starting Price | — | $149.97/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About LevelUp Rx
LevelUp Rx is a telehealth pharmacy offering compounded GLP-1 weight-loss medications - compounded semaglutide and compounded tirzepatide - alongside a broad menu of men's and women's health treatments. A no-cost online consultation is reviewed by US board-certified physicians, and approved prescriptions ship free from accredited partner pharmacies. Compounded semaglutide starts at $149.97/mo and tirzepatide at $249.97/mo, one flat price regardless of dose.
Read our full LevelUp Rx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
LevelUp Rx
What we like
- Compounded semaglutide ($149.97/mo) and tirzepatide ($249.97/mo) on one platform
- Flat monthly price that never changes with your dose
- No-cost online consultation included with your order
- LegitScript-certified; partner pharmacies named (DiRx and The DrugStore)
- Free shipping with no insurance required
- Published patient-care phone line and email support
Watch-outs
- Compounded only - no brand-name Wegovy, Zepbound, Ozempic or Mounjaro
- No single prescribing medical group named; physicians listed only for CA, MA, RI and VT
- State availability is confirmed during intake, not published as a list
- Prescription sales are final once shipped; no returns on dispensed medication
Our Verdict
LevelUp Rx edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for compounded semaglutide and tirzepatide at a flat price with named pharmacies. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose LevelUp Rx if…
You want compounded semaglutide and tirzepatide at a flat price with named pharmacies and a starting price around $149.97/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →Trimi Health
Budget-conscious shoppers
From $99/mo
Get started →ShedRx
Mainstream telehealth GLP-1 access
From $149/mo
Get started →1st Optimal vs LevelUp Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and LevelUp Rx head-to-heads in the same category.
- 1st Optimal vs Amazon One Medical
- 1st Optimal vs Vytora Health
- 1st Optimal vs CoreAge Rx
- LevelUp Rx vs EverSlim
- LevelUp Rx vs Found
- LevelUp Rx vs NewSelf
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.