1st Optimal vs LevelsRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →LevelsRx
Best for: people wanting oral or injectable glp-1 with a weight-loss money-back guarantee
Visit LevelsRx →1st Optimal and LevelsRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $150/mo, and LevelsRx edges ahead overall (7.0 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
LevelsRx
Injectable or oral liposomal liquid; starting price
Starting price; injectable
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
LevelsRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
LevelsRx
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | LevelsRx |
|---|---|---|
| Starting Price | ✓$99/mo | $150/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About LevelsRx
LevelsRx is a US direct-to-consumer telehealth offering compounded GLP-1 weight-loss medication, including compounded semaglutide (injectable and an oral liposomal liquid) starting at 150 dollars per month and compounded tirzepatide starting at 240 dollars per month, plus Sermorelin. Care is fully virtual with licensed providers, same-day slots, and unlimited online visits, and the program advertises a weight-loss money-back warranty if targets are not met. Compounded meds are not FDA-approved. Support is by phone and email with 24-7 availability.
Read our full LevelsRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
LevelsRx
What we like
- Both injectable and oral semaglutide plus tirzepatide, with same-day virtual visits
- Weight-loss money-back warranty if targets are not met
- 24-7 phone and email support with unlimited online provider visits
Watch-outs
- Compounding pharmacy is not named publicly
- States served are not published on the site
- Prices are 'starting at' figures that may rise with dose
Our Verdict
LevelsRx edges out 1st Optimal with a higher overall score of 7.0/10 and is particularly strong for people wanting oral or injectable glp-1 with a weight-loss money-back guarantee. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose LevelsRx if…
You want people wanting oral or injectable glp-1 with a weight-loss money-back guarantee and a starting price around $150/mo.
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Wellorithm
Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →YourEra
$99 first-month entry pricing on compounded GLP-1s
From $149/mo
Get started →1st Optimal vs LevelsRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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