1st Optimal vs Jently
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →Jently
Best for: transparent compounded GLP-1 pricing, plus NAD+, peptides and metformin
Visit Jently →1st Optimal and Jently are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Jently starts at $149/mo, and Jently edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Jently
"As low as $149/mo" (homepage)
"As low as $199/mo" (homepage)
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Jently
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Jently
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Jently |
|---|---|---|
| Starting Price | — | $149/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Jently
Jently is a clinician-guided telehealth service offering compounded GLP-1 weight management (semaglutide from $149/mo, tirzepatide from $199/mo) alongside NAD+, peptide therapy (sermorelin, glutathione), and metformin. Care is 100% online through licensed providers on the MD Integrations network. It runs on a monthly subscription and is operated by Jently, LLC, based in Brooklyn, New York.
Read our full Jently review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Jently
What we like
- Compounded semaglutide from $149/mo and tirzepatide from $199/mo — pricing published
- Multi-pillar: GLP-1, NAD+, peptides (sermorelin, glutathione), and metformin
- 100% online with licensed providers via the MD Integrations network
- Subscription can be cancelled anytime through the patient portal
Watch-outs
- Specific pharmacy partner not named on the site
- No refunds once a consultation is completed or a prescription is dispensed
- Not LegitScript-certified (no certification displayed)
- States of operation not published
Our Verdict
Jently edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for transparent compounded GLP-1 pricing, plus NAD+, peptides and metformin. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Jently if…
You want transparent compounded GLP-1 pricing, plus NAD+, peptides and metformin and a starting price around $149/mo.
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Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →Brightmeds
Compounded or brand GLP-1 bundled with TRT and peptides for men
From $100/mo
Get started →Direct Meds
Listed for disclosure only — see its FDA warning and BBB complaints first
From $249/mo
Get started →1st Optimal vs Jently: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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