1st Optimal vs GetRelief Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
GetRelief Rx
Best for: sublingual (non-injectable) compounded GLP-1 drops for the needle-averse
Visit GetRelief Rx →1st Optimal and GetRelief Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, GetRelief Rx starts at $179/mo, and 1st Optimal edges ahead overall (6.7 vs 6.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
GetRelief Rx
$369-$399/mo after initial; $30 off promo x3 months
$299-$329/mo after initial; $30 off promo x3 months
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What’s included
1st Optimal
Inclusions not disclosed.
GetRelief Rx
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
GetRelief Rx
6.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | GetRelief Rx |
|---|---|---|
| Starting Price | — | $179/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About GetRelief Rx
Get Relief RX, LLC (getreliefrx.com) is a Billings, Montana-based telehealth offering compounded SUBLINGUAL semaglutide (6mg, 9mg) and compounded SUBLINGUAL tirzepatide (7.5mg, 13mg, 16mg). NPI 1306697834. BBB accredited (A rating, March 2026). Free online assessment by licensed provider. Multi-state operations (20+ states). Sublingual drops only — no injectable or FDA-approved brand-name options.
Read our full GetRelief Rx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
GetRelief Rx
What we like
- Compounded semaglutide and tirzepatide priced publicly — no login required to see costs
- BBB accredited with an A rating (March 2026)
- Free online assessment with no upfront consultation fee
Watch-outs
- Sublingual drops only — no injectable; this delivery method wasn't studied in the STEP/SURMOUNT trials
- Still sells compounded tirzepatide after the FDA ended compounding enforcement discretion in 2025
- No LegitScript, PCAB, or NABP pharmacy certifications found
- Prescriber credentials listed only as 'licensed clinicians' with no detail on degree type
Our Verdict
1st Optimal edges out GetRelief Rx with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. GetRelief Rx remains a solid alternative, especially if you're looking for sublingual (non-injectable) compounded GLP-1 drops for the needle-averse.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose GetRelief Rx if…
You want sublingual (non-injectable) compounded GLP-1 drops for the needle-averse and a starting price around $179/mo.
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From $149.25/mo
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Get started →1st Optimal vs GetRelief Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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