1st Optimal vs GetRelief Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programGetRelief Rx
Best for sublingual (non-injectable) compounded GLP-1 drops for the needle-averseStarting at $179/mo
Side-by-Side Comparison
| Feature | 1st Optimal | GetRelief Rx |
|---|---|---|
| Overall Score | ✓6.7/10 | 6.1/10 |
| Starting Price | — | $179/mo |
| Editorial Rating | ✓3.4 ★ /5 | 3.1 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
Pros
- ✓Offers both semaglutide and tirzepatide with injectable and oral formats
- ✓Functional-medicine approach with at-home labs and blood-work interpretation
- ✓Unlimited coaching and ongoing support included
- ✓No long-term contracts
- ✓Board-certified doctors and nurse practitioners referenced
Cons
- ✗No public monthly pricing disclosed
- ✗No published state availability list
- ✗Compounded vs branded sourcing not clarified on site
- ✗Pricing only revealed after quiz or consultation
GetRelief Rx
Pros
- ✓Compounded semaglutide and tirzepatide priced publicly — no login required to see costs
- ✓BBB accredited with an A rating (March 2026)
- ✓Free online assessment with no upfront consultation fee
Cons
- ✗Sublingual drops only — no injectable; this delivery method wasn't studied in the STEP/SURMOUNT trials
- ✗Still sells compounded tirzepatide after the FDA ended compounding enforcement discretion in 2025
- ✗No LegitScript, PCAB, or NABP pharmacy certifications found
- ✗Prescriber credentials listed only as 'licensed clinicians' with no detail on degree type
Our Verdict
1st Optimal edges out GetRelief Rx with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. GetRelief Rx remains a solid alternative, especially if you're looking for sublingual (non-injectable) compounded GLP-1 drops for the needle-averse.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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