1st Optimal vs Factor Health MD
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programFactor Health MD
Best for broadest GLP-1 lineup — semaglutide, tirzepatide and liraglutideStarting at $99/mo
Side-by-Side Comparison
| Feature | 1st Optimal | Factor Health MD |
|---|---|---|
| Overall Score | ✓6.7/10 | 6.4/10 |
| Starting Price | — | $99/mo |
| Editorial Rating | ✓3.4 ★ /5 | 3.2 ★ /5 |
| Features | 8 features | 8 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
Pros
- ✓Offers both semaglutide and tirzepatide with injectable and oral formats
- ✓Functional-medicine approach with at-home labs and blood-work interpretation
- ✓Unlimited coaching and ongoing support included
- ✓No long-term contracts
- ✓Board-certified doctors and nurse practitioners referenced
Cons
- ✗No public monthly pricing disclosed
- ✗No published state availability list
- ✗Compounded vs branded sourcing not clarified on site
- ✗Pricing only revealed after quiz or consultation
Factor Health MD
Pros
- ✓Three-GLP-1 lineup including liraglutide — rare in DTC and useful for patients sensitive to newer molecules
- ✓Aggressive $99/mo starting tier with all doses included
- ✓Multi-product platform (GLP-1, longevity, vitamin injectables, men's health, bundles)
- ✓HSA/FSA accepted — uncommon for compounded GLP-1
- ✓St. Petersburg, FL location and phone (305-930-8817) for accountability
- ✓LegitScript verification badge displayed
- ✓Free medical consultations
- ✓Price doesn't increase per dose as patients titrate up
Cons
- ✗503A/503B pharmacy partner not named
- ✗Full states-served list not disclosed
- ✗No named medical director
- ✗FDA compounded-medication disclaimer not prominently displayed
- ✗Corporate legal entity not disclosed
- ✗Governing law and arbitration venue not disclosed
- ✗Compounded liraglutide has a weaker weight-loss evidence base than semaglutide or tirzepatide
- ✗Tirzepatide tier ($149/mo) less prominent than the advertised $99 starting price
Our Verdict
1st Optimal edges out Factor Health MD with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. Factor Health MD remains a solid alternative, especially if you're looking for broadest GLP-1 lineup — semaglutide, tirzepatide and liraglutide.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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