1st Optimal vs CLYR Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
CLYR Health
Best for: Flat-rate compounded GLP-1 with pricing that does not increase as your dose goes up
Visit CLYR Health →1st Optimal and CLYR Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, CLYR Health starts at $229/mo, and CLYR Health edges ahead overall (7.7 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
CLYR Health
Flat any-dose $229/mo; 3-month prepay $189/mo ($567 billed once)
$249/mo standard dose (up to 3mL); 3-month prepay $199/mo; higher dose 4-8mL $349/mo
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What’s included
1st Optimal
Inclusions not disclosed.
CLYR Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
CLYR Health
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | CLYR Health |
|---|---|---|
| Starting Price | — | $229/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About CLYR Health
CLYR Health is a Florida-based telehealth pharmacy offering compounded GLP-1 weight-loss injections alongside sexual-health, longevity and wellness treatments. It sells compounded semaglutide + B12 from $229/mo and compounded tirzepatide + B12 from $249/mo on flat 'any dose, one price' billing, with 3-month prepay plans that lower the effective rate. Brand Zepbound and oral GLP-1 options are also listed. LegitScript Certified and fulfilled by a named 503A pharmacy.
Read our full CLYR Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
CLYR Health
What we like
- Flat 'any dose, one price' billing so the monthly cost does not rise as your dose climbs
- LegitScript Certified with a named 503A pharmacy partner (The Pharmacy Hub, Miami FL) and MD Integrations clinicians
- 3-month prepay drops semaglutide to $189/mo and tirzepatide to $199/mo
Watch-outs
- State availability gated behind intake; not published on the marketing site
- Standing monthly rates ($229-249) run above the cheapest compounded competitors
- Broad catalog (weight loss, sexual health, longevity) rather than a weight-loss specialist
Our Verdict
CLYR Health edges out 1st Optimal with a higher overall score of 7.7/10 and is particularly strong for Flat-rate compounded GLP-1 with pricing that does not increase as your dose goes up. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose CLYR Health if…
You want Flat-rate compounded GLP-1 with pricing that does not increase as your dose goes up and a starting price around $229/mo.
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DudeMeds
Men seeking no-fee GLP-1 access with oral and injectable options
From $175/mo
Get started →Oak
Compounded semaglutide and tirzepatide at a flat monthly price
From $119/mo
Get started →Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →1st Optimal vs CLYR Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.