1st Optimal vs CeliaRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
CeliaRx
Best for: shoppers who want GLP-1 plus a wider peptide catalog, priced per product, not by subscription
Visit CeliaRx →1st Optimal and CeliaRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $125/mo, and CeliaRx edges ahead overall (7.3 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
CeliaRx
One-time per-bottle purchase; no recurring/auto-ship subscription observed in cart or checkout.
One-time per-bottle purchase; pricing rises by dose per the site's own product listing.
One-time per-bottle purchase.
Site displays this as "$399.00 $200.00/mo, 2 month supply 1 vial" -- a single $399 charge for the whole vial, not a recurring $200 monthly charge.
Site displays this as "$499.00 $125.00/mo, ~4 month supply 1 vial" -- a single $499 charge for the whole vial, not a recurring $125 monthly charge. This is the lowest published per-month average on the site.
One-time per-bottle purchase.
One-time per-bottle purchase.
Site displays this as "$699.00 $350.00/mo, 2 month supply 1 vial" -- a single $699 charge for the whole vial, not a recurring $350 monthly charge.
Site displays this as "$899.00 $225.00/mo, ~4 month supply 1 vial" -- a single $899 charge for the whole vial, not a recurring $225 monthly charge.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
CeliaRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
CeliaRx
7.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | CeliaRx |
|---|---|---|
| Starting Price | ✓$99/mo | $125/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About CeliaRx
CeliaRx is a longevity-focused telehealth marketplace selling compounded semaglutide and tirzepatide as oral dissolving tablets or B12-combo injectables, alongside a broader peptide catalog for skin, hair, gut, and brain health. Prescriptions are compounded by Partell Pharmacy and require a clinician screening completed after checkout, with a full refund if the clinician doesn't approve. Pricing runs from about $199/month for tablets to injectable vials averaging as low as $125-$225/month.
Read our full CeliaRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
CeliaRx
What we like
- Both semaglutide and tirzepatide sold as oral dissolving tablets or B12-combo injectables
- LegitScript-certified — seal independently verified
- Full pricing is visible on product pages with no account, login, or quiz required
- Full refund if the reviewing clinician decides treatment isn't appropriate
- Names its compounding pharmacy (Partell Pharmacy) directly on every product label
- Sells a broader peptide/longevity catalog beyond GLP-1 (skin, hair, gut, brain, libido)
Watch-outs
- State-availability claims conflict across the site's own shipping-policy page
- Payment is collected at checkout before the required medical screening is completed
- Two different legal entity names appear across its own Terms pages (Celia Group, Inc. and Celia Health, LLC)
- No phone support listed -- email only (Mon-Fri, 9am-5pm ET)
- General platform terms call transactions non-refundable, though product pages promise a refund if not approved
- No Trustpilot, Google, or BBB rating badge found to independently verify reputation
- Injectable vial prices are multi-month upfront charges; the advertised "/mo" figure is an average, not a monthly bill
Our Verdict
CeliaRx edges out 1st Optimal with a higher overall score of 7.3/10 and is particularly strong for shoppers who want GLP-1 plus a wider peptide catalog, priced per product, not by subscription. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose CeliaRx if…
You want shoppers who want GLP-1 plus a wider peptide catalog, priced per product, not by subscription and a starting price around $125/mo.
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Mainstream telehealth GLP-1 access
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Get started →altRX
The only platform offering all four brand-name GLP-1s plus compounded
From $149/mo
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Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →1st Optimal vs CeliaRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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