1st Optimal vs Breeze Meds
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Breeze Meds
Best for: compounded GLP-1 access with named prescribers and 4-pharmacy network
Visit Breeze Meds →1st Optimal and Breeze Meds are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Breeze Meds starts at $169/mo, and Breeze Meds edges ahead overall (7.4 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Breeze Meds
Displayed on rendered homepage card 'GLP-1 Injection / Starting at $199'. Checkout catalog JS shows monthly:199 with oldPrice:249 and bundles threeMonthly:748 / sixMonthly:1248 / yearly:2298 ($191.50/mo effective).
Homepage card displays 'Starting at $399'. The site's own checkout catalog (/_nuxt/tdPmVDYT.js) prices it monthly:299 with oldPrice:399 (bundles 1068/3mo, 1918/6mo, 3498/yr) — but checkout is intake-gated, so $299 was found in code, not rendered publicly; keep $399 as the published price and treat $299 as an unconfirmed in-checkout promo.
Rendered card 'Oral Semaglutide / Starting at $299 / One dissolvable tablet per day.' Catalog bundles: 899/3mo, 1799/6mo, 3498/yr.
Rendered card 'Oral Tirzepatide / Starting at $399 / One dissolvable tablet per day.' Catalog bundles: 1199/3mo, 2399/6mo, 4799/yr.
Rendered homepage 'Starting at $169 / NAD+ Injections'. Catalog also lists NAD+ Nasal Spray $210/mo and Sermorelin monthly:135 (marketing card says 'Starting at $100' — internally inconsistent); non-GLP-1 add-ons.
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What’s included
1st Optimal
Inclusions not disclosed.
Breeze Meds
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Breeze Meds
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Breeze Meds |
|---|---|---|
| Starting Price | — | $169/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Breeze Meds
Breeze Meds is a Georgia-based telehealth provider offering compounded semaglutide ($199/mo), tirzepatide ($399/mo), and NAD+ ($169/mo) across all 50 states. LegitScript certified; named medical team (Dr. Ana Lisa Carr MD, Dr. Kelly Tenbrink MD) and a 4-pharmacy compounding network (Belmar, Strive, Epiq Scripts, Casa Pharma Rx) via Lion MD.
Read our full Breeze Meds review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Breeze Meds
What we like
- Available in all 50 states
- LegitScript Certified
- Publicly named medical team: Dr. Ana Lisa Carr, MD and Dr. Kelly Tenbrink, MD
- Four named 503A pharmacy partners: Belmar, Strive, Epiq Scripts, and Casa Pharma Rx
- Semaglutide and tirzepatide offered in both injectable and oral forms
- No FDA warning letters or litigation on record
Watch-outs
- Shares the same clinician network and pharmacies as Care Bare Rx and Synergy Rx — three storefronts on one operation, not independent providers
- Compounded medications are not FDA-approved
- Compounded vs. brand-name sourcing is unclear on the product pages
- Terms of Service page returns a 404 (only the Privacy Policy is present)
- Insurance acceptance isn't clearly disclosed beyond FSA/HSA eligibility
Our Verdict
Breeze Meds edges out 1st Optimal with a higher overall score of 7.4/10 and is particularly strong for compounded GLP-1 access with named prescribers and 4-pharmacy network. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Breeze Meds if…
You want compounded GLP-1 access with named prescribers and 4-pharmacy network and a starting price around $169/mo.
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MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Breeze Meds
Compounded GLP-1 access with named prescribers and 4-pharmacy network
From $169/mo
Get started →1st Optimal vs Breeze Meds: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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