1st Optimal vs Aspire Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Aspire Health
Best for: Nebraska telehealth: compounded + brand GLP-1s with labs included
Visit Aspire Health →1st Optimal and Aspire Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $205/mo, and Aspire Health edges ahead overall (6.9 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Aspire Health
Verbatim from weight-loss page: '$149' for 5-week supply of compounded semaglutide/B6 (low dose 0.25–0.5 mg) + $75/month LoseIt program fee = ~$205/month total. 'Medication costs are not included in either program fee.' 15-week supply listed at $399 (~$115/mo for medication alone). program fee enrollment fee $200 ($175 online).
Verbatim from weight-loss page: '$199' for 5-week supply of compounded semaglutide/B6 (high dose 1.7+ mg) + $75/month LoseIt program fee = ~$247/month total. 15-week supply listed at $499 (~$144/mo for medication alone). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$199' for 4-week supply of Wegovy (brand semaglutide, starter doses) + $75/month LoseIt program fee = ~$274/month total. Other Wegovy doses listed at $399/4 weeks (~$474/mo total with program fee). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$249' for 5-week supply of compounded tirzepatide/B6 (2.5 mg) + $75/month LoseIt program fee = ~$289/month total. 15-week supply at $699 (~$202/mo for medication alone). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$349' for 5-week supply of compounded tirzepatide/B6 (5–15 mg) + $75/month LoseIt program fee = ~$375/month total. 15-week supply at $999 (~$289/mo for medication alone). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$299' for 4-week supply of Zepbound (brand tirzepatide, 2.5 mg) + $75/month LoseIt program fee = ~$374/month total. Higher doses (7.5–15 mg) listed at $449/4wks (~$524/mo total with program fee). 'Medication costs are not included in either program fee.'
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Aspire Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Included
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Aspire Health
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Aspire Health |
|---|---|---|
| Starting Price | ✓$99/mo | $205/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Aspire Health
Aspire Health is a Nebraska-based telehealth practice offering both compounded semaglutide/tirzepatide (formulated with B6) and brand-name Wegovy and Zepbound, prescribed by a named PA/NP clinical team. The LoseIt membership ($200 enrollment + $75/month) includes lab orders with interpretation, provider visits every 2–3 months, Slimpossible app access, and ongoing support — with medication billed separately starting at $149 per 5-week supply for compounded semaglutide.
Read our full Aspire Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Aspire Health
What we like
- Both compounded and brand-name options (Wegovy + Zepbound) — rare among GLP-1 telehealth providers
- Lab orders with interpretation included in LoseIt membership — not billed separately
- Named clinical team: founded by Jenni Haan, MPAS, PA-C (18+ years experience) with four additional credentialed providers
- Slimpossible app + secure messaging for ongoing support between provider visits
- HSA/FSA accepted; Cherry third-party financing available for patients needing payment plans
Watch-outs
- Membership fee ($75/month) stacks on top of separately billed medication — total spend $205–$524/month depending on dose
- No LegitScript certification or independent third-party accreditation disclosed
- States served not publicly listed; availability depends on individual provider licensure
- All medication sales are final once shipped; consultation fee non-refundable once completed
- Compounding pharmacy partner not named on any public page
Our Verdict
Aspire Health edges out 1st Optimal with a higher overall score of 6.9/10 and is particularly strong for Nebraska telehealth: compounded + brand GLP-1s with labs included. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Aspire Health if…
You want Nebraska telehealth: compounded + brand GLP-1s with labs included and a starting price around $205/mo.
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Sesame Care
Brand-name GLP-1s at cash prices, no compounding
From $25/mo
Get started →Try Ageless
Lowest-tier compounded GLP-1 in injection, troche and sublingual forms
From $119/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $88/mo
Get started →1st Optimal vs Aspire Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.