10rx vs Knownwell
An in-depth comparison of two leading GLP-1 Providers
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Knownwell
Best for: branded GLP-1s with obesity-medicine oversight and insurance options
Visit Knownwell →10rx and Knownwell are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 10rx starts lower at $96.67/mo versus $299/mo, and Knownwell edges ahead overall (7.7 vs 7.1 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
10rx
Knownwell
Every Zepbound dose is the same price. Wegovy is $349/mo.
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What’s included
10rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Knownwell
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
7.1/10
Knownwell
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | Knownwell |
|---|---|---|
| Starting Price | ✓$96.67/mo | $299/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 10rx
10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin also offered for energy and recovery. You take a free online health quiz, a board-certified telehealth doctor reviews your history and prescribes if appropriate, and licensed pharmacy partners ship discreetly. 10rx says it ships to all 50 states, but it doesn't publish its operating company, name its pharmacies, or post a terms page.
Read our full 10rx review →About Knownwell
Knownwell is a weight-inclusive metabolic and primary care company co-founded by obesity-medicine specialist Dr. Angela Fitch. It offers branded GLP-1 medications including Wegovy, Zepbound, Ozempic and Saxenda, plus the oral GLP-1 Foundayo, via virtual visits in all 50 states and in-person clinics in Boston, Chicago, Dallas-Fort Worth and Atlanta. Knownwell is a LillyDirect care provider and a Novo Nordisk telehealth partner for the Wegovy pill. Care combines physician oversight with dietitians and coaches. Many insurance plans are accepted, with copays as low as $25 for covered patients.
Read our full Knownwell review →Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to verify
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
Knownwell
What we like
- Co-founded by obesity-medicine specialist Dr. Angela Fitch
- Branded FDA-approved GLP-1s (Wegovy, Zepbound, Ozempic, Saxenda)
- Official LillyDirect provider and Novo Wegovy-pill telehealth partner
- Accepts insurance, copays as low as $25 for covered patients
- Weight-inclusive care with dietitians and health coaches
- Both virtual (50 states) and in-person clinic options
Watch-outs
- Specific self-pay monthly medication prices not transparently posted
- In-person clinics limited to four metro areas
- Branded-only focus can mean higher cost than compounded routes
Our Verdict
Knownwell edges out 10rx with a higher overall score of 7.7/10 and is particularly strong for branded GLP-1s with obesity-medicine oversight and insurance options. 10rx remains a solid alternative, especially if you're looking for low-cost compounded GLP-1 with NAD+ and sermorelin add-ons.
Choose 10rx if…
You want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons and a starting price around $96.67/mo.
Choose Knownwell if…
You want branded GLP-1s with obesity-medicine oversight and insurance options and a starting price around $299/mo.
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Get started →10rx vs Knownwell: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.