Question 1

How long can I keep my Wegovy pen at room temperature?

Accepted Answer

Per the FDA-approved Wegovy label (DailyMed), Wegovy can be stored at temperatures up to 30°C (86°F) for up to 28 days after first use. Beyond 28 days at room temperature, discard the pen even if drug remains. Refrigerated storage (2-8°C / 36-46°F) is the default.

Question 2

Why does Ozempic last 56 days at room temperature but Wegovy only 28?

Accepted Answer

The FDA-approved labels list a 56-day in-use room-temperature period for Ozempic and a 28-day period for Wegovy. The two products have different formulation concentrations (Ozempic 1.34-2.68 mg/mL vs Wegovy higher-strength single-dose presentations) and the manufacturer ran different stability studies. The label is the authoritative source for each drug.

Question 3

What's the in-use period for Mounjaro and Zepbound?

Accepted Answer

Both Mounjaro (DailyMed SetID d2d7da5d-ad07-4228-955f-cf7e355c8cc0) and Zepbound (DailyMed SetID 487cd7e7-434c-4925-99fa-aa80b1cc776b) are stable at temperatures up to 30°C (86°F) for 21 days. Beyond that, discard. Both labels were revised 4/2026.

Question 4

How long does compounded semaglutide last?

Accepted Answer

Compounded products' Beyond-Use-Date (BUD) is set by the dispensing pharmacy per USP <797> conventions. Typical refrigerated BUDs for compounded semaglutide are 14-28 days, but the exact BUD depends on the pharmacy's documented stability validation for the specific formulation. Always defer to the BUD printed on YOUR vial label by the dispensing pharmacy. If your label and this calculator disagree, follow the pharmacy label.

Question 5

What if my pen was left in a hot car?

Accepted Answer

If your pen was at temperatures above 30°C (86°F) for sustained periods (more than a few hours), the FDA-label storage conditions are violated and you should discard the pen and contact your pharmacy for a replacement. Brief exposure (e.g., a few minutes during transit) is generally acceptable per the FDA label, but use clinical judgment — when in doubt, contact your prescriber.

Question 6

Do oral GLP-1 tablets (Rybelsus, Foundayo) have an in-use BUD?

Accepted Answer

No. Oral tablets follow the printed expiration date on the bottle. There is no after-first-use clock the way there is for injectable products. Store oral GLP-1s at room temperature per their FDA-approved labels.

Drug	Refrigerated (until first use)	Room-temp in-use BUD	Refrigerated in-use BUD
Wegovy	Until printed expiration	28 days at ≤30°C	28 days
Ozempic	Until printed expiration	56 days at ≤30°C	56 days
Mounjaro	Until printed expiration	21 days at ≤30°C	21 days
Zepbound	Until printed expiration	21 days at ≤30°C	21 days
Saxenda	Until printed expiration	30 days at ≤30°C	30 days
Rybelsus (oral)	Tablet — store at room temperature; use until printed bottle expiration
Foundayo (oral)	Tablet — store at room temperature; use until printed bottle expiration
Compounded semaglutide	Pharmacy-specific	Pharmacy-specific	Typically 14-28 days (USP <797>)
Compounded tirzepatide	Pharmacy-specific	Pharmacy-specific	Typically 14-28 days (USP <797>)

When should I discard my GLP-1 vial or pen?

Storage rules for Wegovy (semaglutide injection)

GLP-1 in-use Beyond-Use Date reference table (FDA labels)

Related guides

References

Glossary references