eGFR (estimated glomerular filtration rate)

Definition

A blood-based estimate of kidney filtration capacity, expressed in mL/min/1.73m². Normal is ≥90; <60 sustained 3+ months defines chronic kidney disease (CKD). Stage 4 CKD is eGFR 15-29; stage 5 (kidney failure) is <15. The FLOW trial showed semaglutide reduced major kidney-disease events 24% in T2D patients with CKD (Perkovic 2024, PMID 38785209), driving the 2025 FDA label expansion for Ozempic to include kidney-disease progression prevention.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

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