Amylin

How GLP-1 receptor agonists work — receptors, gastric emptying, and the satiety pathway.

Definition

A pancreatic hormone co-secreted with insulin that signals satiety via brainstem receptors. Long-acting amylin analogs (cagrilintide) are being studied alone and combined with GLP-1 drugs (CagriSema) to amplify weight loss beyond what GLP-1 monotherapy achieves. Distinct receptor pathway from GLP-1.

CagriSema REDEFINE trial results →

Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in Mechanism

GLP-1 receptor
GIP receptor
Dual agonist
Gastric emptying
Food noise
Triple agonist

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