Amylin
How GLP-1 receptor agonists work — receptors, gastric emptying, and the satiety pathway.
Definition
A pancreatic hormone co-secreted with insulin that signals satiety via brainstem receptors. Long-acting amylin analogs (cagrilintide) are being studied alone and combined with GLP-1 drugs (CagriSema) to amplify weight loss beyond what GLP-1 monotherapy achieves. Distinct receptor pathway from GLP-1.
CagriSema REDEFINE trial results →
Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.
Related terms in Mechanism
- GLP-1 receptor
- GIP receptor
- Dual agonist
- Gastric emptying
- Food noise
- Triple agonist
- GLP-1 tachyphylaxis
- Non-peptide GLP-1 agonist
- A1C (glycated hemoglobin)
- MASH / MASLD
- TBWL (Total Body Weight Loss)
- C-peptide
- eGFR (estimated glomerular filtration rate)
- Visceral adipose tissue (VAT)
- AHI (apnea-hypopnea index)
- SNAC (oral semaglutide absorption enhancer)
Looking for more depth?
- CagriSema REDEFINE trial results
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