AHI (apnea-hypopnea index)
How GLP-1 receptor agonists work — receptors, gastric emptying, and the satiety pathway.
Definition
The number of apneas (breathing pauses ≥10 seconds) plus hypopneas (breathing reductions with oxygen desaturation) per hour of sleep, measured during polysomnography. Diagnostic thresholds: AHI 5-14 = mild OSA, 15-29 = moderate, ≥30 = severe. SURMOUNT-OSA used AHI reduction as its primary endpoint; tirzepatide 15 mg cut AHI by ~25 events/hour vs placebo.
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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.
Related terms in Mechanism
- GLP-1 receptor
- GIP receptor
- Dual agonist
- Gastric emptying
- Food noise
- Triple agonist
- Amylin
- GLP-1 tachyphylaxis
- Non-peptide GLP-1 agonist
- A1C (glycated hemoglobin)
- MASH / MASLD
- TBWL (Total Body Weight Loss)
- C-peptide
- eGFR (estimated glomerular filtration rate)
- Visceral adipose tissue (VAT)
- SNAC (oral semaglutide absorption enhancer)
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