Triple agonist

How GLP-1 receptor agonists work — receptors, gastric emptying, and the satiety pathway.

Definition

A peptide that activates three different metabolic receptors simultaneously — typically GIP, GLP-1, and glucagon. Retatrutide is the first triple agonist in clinical development for weight loss. The glucagon component is hypothesized to add an energy-expenditure effect on top of GLP-1 and GIP appetite suppression.

Retatrutide: triple-agonist evidence →

Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in Mechanism

GLP-1 receptor
GIP receptor
Dual agonist
Gastric emptying
Food noise
Amylin

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Retatrutide: triple-agonist evidence
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