Wholesome Clinic vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Wholesome Clinic
Best for: Multi-state telehealth pairing compounded GLP-1 weight loss with integrative psychiatry
Visit Wholesome Clinic →
Enhance MD
Best for: lab-monitored compounded GLP-1 with mandatory video visit
Visit Enhance MD →Wholesome Clinic and Enhance MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Wholesome Clinic starts lower at $109/mo versus $169/mo, and Enhance MD edges ahead overall (8.2 vs 7.6 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Wholesome Clinic
Self-pay; $109/$149/$199 per month by dose plan
Self-pay; $149-$199+ per month by dose plan
Self-pay; $249/$299/$349 per month by dose plan
Self-pay; $349/$449/$549 per month by dose plan
Enhance MD
$212/mo is the 12-month-plan rate (billed every 48 weeks). 6-mo $224/mo, 3-mo $237/mo, 1-mo $249/mo. First month $112 = $100 off first order on 3+ month plans (code SUMMER100); $50 off 1-month (SUMMER50). Flat price at all doses; labs, consult, 2-day shipping included.
$280/mo = 12-month-plan rate. 6-mo $296/mo, 3-mo $313/mo, 1-mo $329/mo. First month $180 via $100-off first order (SUMMER100). Flat all-dose pricing.
Combined semaglutide + tirzepatide. $322/mo = 12-month-plan rate. 6-mo $341/mo, 3-mo $360/mo, 1-mo $379/mo. First month $222 via SUMMER100.
New low-dose tier: 12-mo $169/mo, 6-mo $179/mo, 3-mo $189/mo; the 1-month plan's price is not displayed on the page (blank slot) — not published. No $100-off promo tags shown on this product's plan picker.
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What’s included
Wholesome Clinic
What the monthly price covers
Medication
Included
Provider visits
Billed separately
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
Enhance MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Included
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Wholesome Clinic
7.6/10
Enhance MD
8.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Wholesome Clinic | Enhance MD |
|---|---|---|
| Starting Price | ✓$109/mo | $169/mo |
| Features | 6 features | 6 features |
| States Available | 7 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Wholesome Clinic
Wholesome Clinic is a Frisco, Texas integrative-psychiatry and wellness practice offering medical weight loss via telehealth across seven states. Providers prescribe compounded semaglutide and tirzepatide (oral dissolving tablet or weekly injectable), plus brand Wegovy and Zepbound when clinically appropriate. Self-pay medication runs from $109/month for compounded semaglutide, with a $149 initial evaluation and $75 follow-ups billed separately.
Read our full Wholesome Clinic review →About Enhance MD
Enhance MD pairs compounded semaglutide and tirzepatide with mandatory baseline metabolic labs at Quest Diagnostics and a synchronous video visit with a board-certified clinician — a more rigorous onboarding than the async-only compounded GLP-1 model most telehealth providers use. Three tiers (Core semaglutide, Advanced tirzepatide, Elite combined) plus $100-off-first-order intro pricing ($112 first month on Core with code SUMMER100).
Read our full Enhance MD review →Pros & Cons
Wholesome Clinic
What we like
- Publishes standing per-dose self-pay prices for compounded semaglutide and tirzepatide, oral and injectable
- Compounded semaglutide from $109/mo (oral) or $149/mo (injectable); brand Wegovy/Zepbound offered when appropriate
- Telehealth across seven states plus an in-person option at its Frisco, TX office
Watch-outs
- $149 initial evaluation and $75 follow-up visits are billed separately from medication
- Filled through your 'preferred pharmacy' — no single named compounding pharmacy partner
- No LegitScript certification displayed
Enhance MD
What we like
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- Intro pricing via $100 off your first order (code SUMMER100): $112 Core, $180 Advanced, $222 Elite first month
- Unlimited clinician messaging and dose-adjustment support included
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- No insurance accepted — cash pay, HSA/FSA eligible
- Intro discount applies only to the first order — ongoing rates are $212–$322/mo on 12-month plans, or $249–$379/mo month-to-month
Our Verdict
Enhance MD edges out Wholesome Clinic with a higher overall score of 8.2/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Wholesome Clinic remains a solid alternative, especially if you're looking for Multi-state telehealth pairing compounded GLP-1 weight loss with integrative psychiatry.
Choose Wholesome Clinic if…
You want Multi-state telehealth pairing compounded GLP-1 weight loss with integrative psychiatry and a starting price around $109/mo.
Choose Enhance MD if…
You want lab-monitored compounded GLP-1 with mandatory video visit and a starting price around $169/mo.
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Get started →Wholesome Clinic vs Enhance MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.