Always verify pricing and state availability on the provider's website before signing up.How our reviews work →

RxSpan MD vs Enhance MD

An in-depth comparison of two leading GLP-1 Providers

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

7.4

RxSpan MD

Best for shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
★★★★☆3.7

Starting at $249/mo

CompoundedSemaglutideTirzepatideBrand-name available
Visit RxSpan MD →
8.6

Enhance MD

Best for lab-monitored compounded GLP-1 with mandatory video visit
★★★★☆4.3

Starting at $212/mo

CompoundedSemaglutideTirzepatideVideo Visit
Visit Enhance MD →

Side-by-Side Comparison

FeatureRxSpan MDEnhance MD
Overall Score7.4/10✓8.6/10
Starting Price$249/mo✓$212/mo
Editorial Rating3.7 ★ /5✓4.3 ★ /5
Features✓7 features6 features
States Available✓5039
Compounded✓ Yes✓ Yes
Brand Name✓ Yes—
FSA/HSA Accepted——
FDA WarningsNoneNone

Pros & Cons

RxSpan MD

What we like

  • Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
  • Compounded semaglutide and tirzepatide from $249/mo (injection or oral capsules), plus brand-name Wegovy, Zepbound and Ozempic
  • Names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group
  • LegitScript-certified (#50405601); free expedited shipping and unlimited 24/7 support included
  • Available in all 50 states via a 2-minute assessment

Watch-outs

  • Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
  • Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
  • Multi-vertical practice (also hair, sexual health, longevity), not weight-loss-only
  • Legal entity name isn't published on the site

Enhance MD

What we like

  • Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
  • Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
  • Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
  • Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
  • Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
  • Unlimited clinician messaging and dose-adjustment support included

Watch-outs

  • Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
  • Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
  • Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
  • No insurance accepted — cash pay, HSA/FSA eligible
  • Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost

Our Verdict

Winner: Enhance MDScore: 8.6/10

Enhance MD edges out RxSpan MD with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. RxSpan MD remains a solid alternative, especially if you're looking for shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options.

Get Started with RxSpan MD →Get Started with Enhance MD →

Key terms, explained

New to GLP-1s? Tap any term for a quick, plain-English definition.

Related comparisons

Continue exploring RxSpan MD and Enhance MD head-to-heads in the same category.

Or see the full category ranking.

Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.