Metabolyz vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Metabolyz
Best for: All-50-state telehealth; compounded sema+tirz+microdose; coaching included; gated pricing
Visit Metabolyz →
Enhance MD
Best for: lab-monitored compounded GLP-1 with mandatory video visit
Visit Enhance MD →Metabolyz and Enhance MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Enhance MD starts at $212/mo, and Enhance MD edges ahead overall (8.6 vs 6.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Metabolyz
Pricing not publicly listed.
Enhance MD
What’s included
Metabolyz
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Included
Enhance MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Included
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Metabolyz
6.8/10
Enhance MD
8.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Metabolyz | Enhance MD |
|---|---|---|
| Starting Price | — | $212/mo |
| Features | ✓8 features | 6 features |
| States Available | ✓50 | 39 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Metabolyz
Metabolyz is a nationwide GLP-1 telehealth platform offering three compounded programs — standard semaglutide, dual-agonist tirzepatide, and a microdose protocol for patients near goal weight or intolerant of standard doses. All programs are physician-supervised across all 50 states, with medication from licensed 503A/503B US pharmacies, temperature-controlled direct delivery, and built-in nutrition and lifestyle coaching. Pricing is not publicly listed and is reviewed during the initial consultation.
Read our full Metabolyz review →About Enhance MD
Enhance MD pairs compounded semaglutide and tirzepatide with mandatory baseline metabolic labs at Quest Diagnostics and a synchronous video visit with a board-certified clinician — a more rigorous onboarding than the async-only compounded GLP-1 model most telehealth providers use. Three tiers (Core semaglutide, Advanced tirzepatide, Elite combined) plus aggressive intro pricing ($49 first month on Core).
Read our full Enhance MD review →Pros & Cons
Metabolyz
What we like
- Three GLP-1 programs: standard semaglutide, dual-agonist tirzepatide, and a microdose protocol for near-goal or dose-sensitive patients
- Nutrition, movement, and lifestyle coaching included in all programs at no extra charge
- Medication compounded in licensed 503A/503B US pharmacies with temperature-controlled, unmarked direct-to-door delivery
- Licensed provider supervision with direct messaging access and structured check-ins throughout
- Telehealth across all 50 states; BMI 27+ eligibility (25+ with weight-related condition)
Watch-outs
- Pricing is fully gated — not disclosed until after consultation, preventing upfront cost comparison
- Compounded GLP-1 only — no brand-name options (Wegovy, Zepbound) available
- No LegitScript certification or named medical leadership found on public-facing pages
- Labs not mentioned as included — unclear whether baseline or follow-up bloodwork is offered
- Newer brand with no external reviews, published outcomes data, or notable accreditations
Enhance MD
What we like
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- Unlimited clinician messaging and dose-adjustment support included
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- No insurance accepted — cash pay, HSA/FSA eligible
- Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Metabolyz with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Metabolyz remains a solid alternative, especially if you're looking for All-50-state telehealth; compounded sema+tirz+microdose; coaching included; gated pricing.
Choose Metabolyz if…
You want All-50-state telehealth; compounded sema+tirz+microdose; coaching included; gated pricing.
Choose Enhance MD if…
You want lab-monitored compounded GLP-1 with mandatory video visit and a starting price around $212/mo.
Ready to start? Vetted GLP-1 providers
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Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $49/mo
Get started →Embody
Lowest first-month entry pricing on compounded GLP-1s
From $99/mo
Get started →TrimRx
Best overall value
From $179/mo
Get started →Metabolyz vs Enhance MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.