Helios Meds vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Helios Meds
Best for: Transparent low-cost compounded semaglutide from a LegitScript-approved telehealth provider
Visit Helios Meds →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Helios Meds and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $149.99/mo, and NewSelf edges ahead overall (8.3 vs 7.0 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Helios Meds
NewSelf
All dosages same price
All dosages same price
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What’s included
Helios Meds
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Helios Meds
7.0/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Helios Meds | NewSelf |
|---|---|---|
| Starting Price | $149.99/mo | ✓$100/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Helios Meds
Helios Meds is a US telehealth provider based in Hockessin, Delaware offering physician-prescribed compounded GLP-1 medications for weight loss, with US board-certified physicians and LegitScript approval. Compounded semaglutide starts at $149.99/month and compounded tirzepatide at $349.97/month, with an online provider review and discreet shipping. Pricing is transparent; a public state list is not enumerated on the site.
Read our full Helios Meds review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Helios Meds
What we like
- Transparent compounded pricing: semaglutide from $149.99/month
- Compounded semaglutide and tirzepatide via online provider review
- LegitScript-approved with US board-certified physicians
- Discreet shipping
Watch-outs
- Compounded GLP-1s are not FDA-approved finished products
- Tirzepatide is relatively pricey at $349.97/month
- Public state list is not enumerated
- Cash-pay only — no insurance billing
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Helios Meds with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Helios Meds remains a solid alternative, especially if you're looking for Transparent low-cost compounded semaglutide from a LegitScript-approved telehealth provider.
Choose Helios Meds if…
You want Transparent low-cost compounded semaglutide from a LegitScript-approved telehealth provider and a starting price around $149.99/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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ShedRx
Mainstream telehealth GLP-1 access
From $149/mo
Get started →bmiMD
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →Helios Meds vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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