He & She MD vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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He & She MD
Best for Transparent low intro-priced GLP-1 (injectable, oral, or microdose) with brand-name accessStarting at $99/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | He & She MD | Enhance MD |
|---|---|---|
| Overall Score | 7.4/10 | ✓8.6/10 |
| Starting Price | $99/mo | ✓$49/mo |
| Editorial Rating | 3.7 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | ✓50 | 39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
He & She MD
Pros
- ✓Transparent intro pricing: injectable GLP-1 from $139/month, oral from $199, microdose from $99
- ✓Compounded semaglutide and tirzepatide (injectable or oral) plus brand access to Ozempic, Wegovy, Zepbound
- ✓Only charged if medication is prescribed; no hidden fees
- ✓Free expedited shipping and unlimited board-certified clinician access
- ✓GLP-1 coaching, nutrition guidance, and in-app progress tracking
- ✓LegitScript-certified with named FDA-registered pharmacy partners
- ✓Ships to 49 states (all except Louisiana)
Cons
- ✗Compounded GLP-1s are not FDA-approved finished products (per the site FDA disclaimer)
- ✗Does not ship to Louisiana or to PO boxes
- ✗Introductory pricing rises after the 6-month (or 3-month microdose) plan
- ✗Cash-pay model — insurance billing not indicated
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out He & She MD with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. He & She MD remains a solid alternative, especially if you're looking for Transparent low intro-priced GLP-1 (injectable, oral, or microdose) with brand-name access.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.