Cost Plus Drugs vs TrimRx
An in-depth comparison of two leading GLP-1 Providers
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Cost Plus Drugs
Best for the cheapest transparent-pricing brand-name Ozempic channelStarting at $279/mo
TrimRx
Best for best overall valueStarting at $199/mo
Side-by-Side Comparison
| Feature | Cost Plus Drugs | TrimRx |
|---|---|---|
| Overall Score | 8.5/10 | ✓9.0/10 |
| Starting Price | $279/mo | ✓$199/mo |
| Editorial Rating | 4.3 ★ /5 | ✓4.5 ★ /5 |
| Features | ✓5 features | 3 features |
| States Available | ✓50 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Cost Plus Drugs
Pros
- ✓Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- ✓Around $279/mo for branded Ozempic — well below typical retail list prices
- ✓Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
- ✓Ships to all 50 states; genuine FDA-approved Novo Nordisk Ozempic, not compounded
- ✓Partnered with 9amHealth so you can get prescribed and fill at Cost Plus pricing
Cons
- ✗Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- ✗Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
- ✗Wegovy availability has been spotty — check current stock before assuming it ships
- ✗No compounded semaglutide or tirzepatide — brand only
- ✗No clinical follow-up — side-effect monitoring falls to your prescribing clinician
TrimRx
Pros
- ✓Both semaglutide and tirzepatide available
- ✓Compounded GLP-1 access
Cons
- ✗Limited public information on program details
Our Verdict
TrimRx edges out Cost Plus Drugs with a higher overall score of 9.0/10 and is particularly strong for best overall value. Cost Plus Drugs remains a solid alternative, especially if you're looking for the cheapest transparent-pricing brand-name Ozempic channel.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
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- Cost Plus Drugs vs Amazon One Medical
- Cost Plus Drugs vs NovoCare Pharmacy
- TrimRx vs Vytora Health
- TrimRx vs Enhance MD
- TrimRx vs Noom Med
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.