Cost Plus Drugs vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Cost Plus Drugs
Best for the cheapest transparent-pricing brand-name Ozempic channelStarting at $279/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Cost Plus Drugs | Enhance MD |
|---|---|---|
| Overall Score | 8.5/10 | ✓8.6/10 |
| Starting Price | $279/mo | ✓$49/mo |
| Editorial Rating | 4.3 ★ /5 | 4.3 ★ /5 |
| Features | 5 features | ✓6 features |
| States Available | ✓50 | 39 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Cost Plus Drugs
Pros
- ✓Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- ✓Around $279/mo for branded Ozempic — well below typical retail list prices
- ✓Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
- ✓Ships to all 50 states; genuine FDA-approved Novo Nordisk Ozempic, not compounded
- ✓Partnered with 9amHealth so you can get prescribed and fill at Cost Plus pricing
Cons
- ✗Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- ✗Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
- ✗Wegovy availability has been spotty — check current stock before assuming it ships
- ✗No compounded semaglutide or tirzepatide — brand only
- ✗No clinical follow-up — side-effect monitoring falls to your prescribing clinician
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Cost Plus Drugs with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Cost Plus Drugs remains a solid alternative, especially if you're looking for the cheapest transparent-pricing brand-name Ozempic channel.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.