Cielo vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Cielo
Best for flat-rate compounded GLP-1 at the lowest 3-month bundle pricesStarting at $115/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Cielo | Enhance MD |
|---|---|---|
| Overall Score | 7.5/10 | ✓8.6/10 |
| Starting Price | $115/mo | ✓$49/mo |
| Editorial Rating | 3.8 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Cielo
Pros
- ✓Among the lowest 3-month bundle prices in compounded GLP-1 ($115/mo semaglutide)
- ✓Single flat price across all doses simplifies titration planning
- ✓Corporate address (St. Petersburg, FL) and customer-service phone published
Cons
- ✗No LegitScript, NABP .pharmacy, or HIPAA badge on the home page
- ✗Pharmacy partner not named (only 'regulated FDA pharmacy partners')
- ✗State coverage list not published — can't verify all-50-state availability
- ✗Clinical care runs through MD Integrations, a shared third-party network used by many brands
- ✗No brand-name Wegovy or Zepbound option
- ✗Donation page shows 0% next to a 10%-pledge claim — an apparent discrepancy
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Cielo with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Cielo remains a solid alternative, especially if you're looking for flat-rate compounded GLP-1 at the lowest 3-month bundle prices.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.