Actin vs Signos
An in-depth comparison of two leading GLP-1 Providers
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Actin
Best for affordable compounded semaglutide with B12 enhancementStarting at $133/mo
Signos
Best for Pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and appStarting at $199/mo
Side-by-Side Comparison
| Feature | Actin | Signos |
|---|---|---|
| Overall Score | 7.0/10 | ✓7.5/10 |
| Starting Price | ✓$133/mo | $199/mo |
| Editorial Rating | 3.5 ★ /5 | ✓3.8 ★ /5 |
| Features | 3 features | ✓8 features |
| States Available | 0 | 0 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
Pros & Cons
Actin
Pros
- ✓Semaglutide paired with B12 for added energy support
- ✓Transparent pricing — exact cost shown upfront with no hidden fees
- ✓Competitive starting price from $133
Cons
- ✗Semaglutide only — no tirzepatide or liraglutide
- ✗No visible LegitScript or PCAB accreditation
- ✗States served not disclosed
- ✗Broad platform spanning hormones, sexual wellness, and hair health
Signos
Pros
- ✓Bundles compounded GLP-1 (semaglutide) with an FDA-cleared CGM and app — glucose-guided weight loss, not just medication
- ✓Starting at $199/mo on a 6-month program, with the CGM included at no extra cost
- ✓Free rapid shipping; HSA/FSA eligible
- ✓Real-time glucose insights and app coaching to help sustain results after GLP-1
Cons
- ✗Compounded GLP-1s are not FDA-approved finished products
- ✗Headline price is a 6-month-program rate, not month-to-month
- ✗Only semaglutide is shown in the program; tirzepatide availability is not confirmed
- ✗Compounding pharmacy partner and state availability are not published on the landing page
Our Verdict
Signos edges out Actin with a higher overall score of 7.5/10 and is particularly strong for Pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app. Actin remains a solid alternative, especially if you're looking for affordable compounded semaglutide with B12 enhancement.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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