1st Optimal vs YOURx Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
YOURx Health
Best for: MD Integrations-network GLP-1 with included lab monitoring
Visit YOURx Health →1st Optimal and YOURx Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, YOURx Health starts at $159/mo, and 1st Optimal edges ahead overall (6.7 vs 6.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
YOURx Health
Self-pay; no insurance accepted. Includes Vitamin B12.
Self-pay; no insurance accepted. Includes Vitamin B12.
Rapid-dissolve oral tablet; self-pay.
Rapid-dissolve oral tablet; self-pay.
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What’s included
1st Optimal
Inclusions not disclosed.
YOURx Health
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
YOURx Health
6.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | YOURx Health |
|---|---|---|
| Starting Price | — | $159/mo |
| Features | ✓8 features | 4 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About YOURx Health
YOURx Health (yourxhealth.com) is a compounded GLP-1 telehealth platform powered by the MD Integrations provider network. The platform offers physician video consultation, medication delivery, regular check-ins, lab monitoring, and easy refills. Pricing is gated behind the qualification questionnaire and patient portal — not publicly displayed. Legal entity name and third-party accreditation NOT publicly disclosed on the home page.
Read our full YOURx Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
YOURx Health
What we like
- Lab monitoring included (per the home page) — most peer platforms gate labs as add-ons or skip them entirely
- Physician video consultation with 'board-certified provider' disclosed
- MD Integrations network is a recognized white-label clinical platform
- Transparent published pricing: semaglutide injection $179/mo, tirzepatide injection $199/mo, oral RDT tablets $159-$179/mo
Watch-outs
- Parent company / legal entity name NOT publicly disclosed — material YMYL transparency gap
- NO LegitScript / NABP / PCAB / BBB seal displayed — material trust-signal gap vs peer platforms
- Per-state availability shown as 'Coverage 0 States' (placeholder metric) — appears the home page is incomplete or the platform is pre-launch
- Pharmacy partners NOT publicly named
- Confidence LOW until the platform exposes more public information
- Does not accept insurance — self-pay only ('we do not accept medical insurance at this time')
Our Verdict
1st Optimal edges out YOURx Health with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. YOURx Health remains a solid alternative, especially if you're looking for MD Integrations-network GLP-1 with included lab monitoring.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose YOURx Health if…
You want MD Integrations-network GLP-1 with included lab monitoring and a starting price around $159/mo.
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YourEra
$99 first-month entry pricing on compounded GLP-1s
From $99/mo
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Compounded GLP-1/GIP combo therapy on a yearly subscription with free shipping nationwide
From $129/mo
Get started →TMates
Nationwide compounded GLP-1 availability including Puerto Rico
From $249/mo
Get started →1st Optimal vs YOURx Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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