1st Optimal vs Tuyo Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →Tuyo Health
Best for: shoppers wanting low-cost compounded glp-1 on an all-inclusive plan
Visit Tuyo Health →1st Optimal and Tuyo Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Tuyo Health starts at $155/mo, and Tuyo Health edges ahead overall (7.1 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Tuyo Health
All-inclusive: protocol, consults, shipping and periodic labs
All-inclusive compounded plan; brand Zepbound also offered separately
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What’s included
1st Optimal
Inclusions not disclosed.
Tuyo Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Tuyo Health
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Tuyo Health |
|---|---|---|
| Starting Price | — | $155/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Tuyo Health
Tuyo Health (tuyohealth.com) is a US telehealth weight-loss program founded by Dr. German Echeverry that offers both compounded and brand-name GLP-1 medication. Compounded semaglutide starts at 155 dollars per month and compounded tirzepatide at 279 dollars per month, all-inclusive with custom protocol, free same-week shipping, complimentary medical consultations and periodic lab work. Brand-name Wegovy and Zepbound plans start around 399 to 499 dollars per month plus a 99 dollar membership, and can be lower with insurance. Support is by phone at 866-642-8054 and email.
Read our full Tuyo Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Tuyo Health
What we like
- Low starting price of 155 dollars per month for compounded semaglutide, all-inclusive
- Offers both compounded and brand-name Wegovy and Zepbound, with an insurance option
- Free same-week shipping, complimentary consults and periodic lab work included
Watch-outs
- Service-area states not published
- No specific compounding pharmacy named on the site
- Brand-name plans add a separate 99 dollar membership fee
Our Verdict
Tuyo Health edges out 1st Optimal with a higher overall score of 7.1/10 and is particularly strong for shoppers wanting low-cost compounded glp-1 on an all-inclusive plan. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Tuyo Health if…
You want shoppers wanting low-cost compounded glp-1 on an all-inclusive plan and a starting price around $155/mo.
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Direct Meds
Listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →Sesame Care
Brand-name GLP-1s (Wegovy, Zepbound) at LillyDirect/NovoCare cash prices — no compounding
From $25/mo
Get started →1st Optimal vs Tuyo Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.