1st Optimal vs TrueMe
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
TrueMe
Best for: flat all-inclusive GLP-1 pricing with no membership fee, if you live in one of its six states
Visit TrueMe →1st Optimal and TrueMe are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, TrueMe starts at $159/mo, and TrueMe edges ahead overall (7.2 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
TrueMe
Compounded semaglutide with added B vitamins. Price covers consultation, medication, shipping, supplies and ongoing provider support. A 3-month plan works out to $119/mo but is billed as a single $357 payment.
Dual-action compounded tirzepatide with added B vitamins. A 3-month plan works out to $139/mo but is billed as a single $417 payment.
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What’s included
1st Optimal
Inclusions not disclosed.
TrueMe
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
TrueMe
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | TrueMe |
|---|---|---|
| Starting Price | — | $159/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 6 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About TrueMe
TrueMe is a cash-pay telehealth brand offering compounded semaglutide and tirzepatide with added B vitamins, alongside NAD+, sermorelin and glutathione. One flat price covers the consult, medication, shipping, supplies and ongoing provider support, with no membership fee and the same price at every dose. GLP-1 starts at $159 and GLP-1/GIP at $189, though both bill every four weeks rather than monthly. Service is currently limited to six states.
Read our full TrueMe review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
TrueMe
What we like
- One price covers consultation, medication, shipping, supplies and provider support, and the site states there are no separate membership fees
- Same price at every dose, so the cost does not climb as a provider titrates the dose upward
- Full pricing is published up front — no intake form is required before you can see what you will pay
- Carries a genuine LegitScript-issued seal (ID 50205625) that resolves on LegitScript's own asset host
- Names its telehealth platform (Telegra) and physician network (Strive), and the returns address names CarePoint Infusion Pharmacy in Stafford, Texas
- Checkout states plainly that the order is not complete until the health questionnaire is finished
- Says any charge is refunded if a provider decides treatment is not medically appropriate
- Also publishes prices for NAD+ and sermorelin at $149/mo month-to-month, which most peptide sellers do not
Watch-outs
- Serves only six states (AZ, CO, MO, PA, TX, WI), far narrower coverage than most national GLP-1 telehealth
- Prices marketed per month are charged every 4 weeks at checkout — 13 charges a year, not 12
- You pay before completing the medical intake, and approval is not guaranteed at the moment you are charged
- The 3-month rates ($119 and $139/mo) are a single upfront charge of $357 or $417, not a lower monthly plan
- A Featured In strip shows CNN, Fox News, Forbes, New York Times and NPR logos with no linked coverage
- No clinicians or founders are named anywhere on the site, and the FAQ says the dispensing pharmacy may vary
- The refund policy says TrueMe does not ship refrigerated products while the FAQ describes cold-chain shipping
- Homepage lists five service states while every treatment page lists six, and unedited template copy remains
Our Verdict
TrueMe edges out 1st Optimal with a higher overall score of 7.2/10 and is particularly strong for flat all-inclusive GLP-1 pricing with no membership fee, if you live in one of its six states. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose TrueMe if…
You want flat all-inclusive GLP-1 pricing with no membership fee, if you live in one of its six states and a starting price around $159/mo.
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Get started →1st Optimal vs TrueMe: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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