1st Optimal vs RxSaludable
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
RxSaludable
Best for: Spanish-speaking patients who want compounded GLP-1 care from Spanish-speaking providers
Visit RxSaludable →1st Optimal and RxSaludable are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, RxSaludable starts at $179/mo, and RxSaludable edges ahead overall (7.6 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
RxSaludable
3-month plan: $99 first month then $179/mo; monthly plan $199 ($119 first month)
3-month plan: $189 first month then $269/mo; monthly plan $289 ($209 first month)
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 420+ providers' prices on their own sites and email you when tracked prices move.
What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
RxSaludable
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
RxSaludable
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | RxSaludable |
|---|---|---|
| Starting Price | — | $179/mo |
| Features | ✓8 features | 7 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About RxSaludable
RxSaludable is a Spanish-language GLP-1 weight-loss telehealth service (atencion en espanol) offering compounded semaglutide from $99 the first month ($179/mo after) and tirzepatide from $189 the first month, prescribed by U.S.-licensed, Spanish-speaking providers and shipped free. Pricing is the same at every dose with no membership fee; the brand also offers microdose GLP-1, sermorelin, NAD+ and glutathione.
Read our full RxSaludable review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
RxSaludable
What we like
- Spanish-language platform with Spanish-speaking, U.S.-licensed providers — a genuine gap in GLP-1 telehealth
- Compounded semaglutide $99 first month ($179/mo after) and tirzepatide $189 first month; same price at every dose, no membership fee
- LegitScript-certified (#50274281); free expedited shipping; named obesity-medicine physicians
- Same-day doctor visits, 24/7 support, FSA/HSA eligible, cancel anytime
Watch-outs
- Ongoing prices ($179-289/mo) are mid-range once the first-month intro ends
- Doesn't name its compounding pharmacy partners (generic 'certified pharmacies')
- No legal entity name or explicit state-coverage list published on the site
- Compounded GLP-1s are not FDA-approved (the site discloses this)
Our Verdict
RxSaludable edges out 1st Optimal with a higher overall score of 7.6/10 and is particularly strong for Spanish-speaking patients who want compounded GLP-1 care from Spanish-speaking providers. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose RxSaludable if…
You want Spanish-speaking patients who want compounded GLP-1 care from Spanish-speaking providers and a starting price around $179/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $159/mo
Get started →MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →Oak
Compounded semaglutide and tirzepatide at a flat monthly price
From $119/mo
Get started →1st Optimal vs RxSaludable: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and RxSaludable head-to-heads in the same category.
- 1st Optimal vs Amazon One Medical
- 1st Optimal vs Vytora Health
- 1st Optimal vs CoreAge Rx
- RxSaludable vs EverSlim
- RxSaludable vs Found
- RxSaludable vs NewSelf
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.