1st Optimal vs RegenCen
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
RegenCen
Best for: Women in MI or FL wanting GLP-1 weight loss alongside menopause and hormone care
Visit RegenCen →1st Optimal and RegenCen are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both land at 6.7/10 overall. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
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Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
RegenCen
6.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | RegenCen |
|---|---|---|
| Starting Price | — | — |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 2 |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About RegenCen
RegenCen is a women's and menopause-focused practice offering its Medically Guided Weight Loss program with GLP-1 medications including semaglutide and tirzepatide, paired with peptides, metabolic care, and coaching. Virtual consultations by video or phone are available to patients in Michigan and Florida, alongside physical locations in both states and Bluffton, South Carolina. The clinic is led by Dr. Gustav Lo, MD and Courtney Lo, PA, and includes Menopause Society Certified Practitioners. It emphasizes hormone support via its RegenHRT approach. Specific GLP-1 prices are not published.
Read our full RegenCen review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
RegenCen
What we like
- Virtual consultations by video or phone for MI and FL patients
- MD-led oversight (Dr. Gustav Lo) plus PA co-founder
- Menopause Society Certified Practitioners on staff
- GLP-1 paired with coaching and metabolic care
- Bundles weight loss with bioidentical hormone therapy
Watch-outs
- Telehealth limited to Michigan and Florida
- No published GLP-1 medication pricing
- No named pharmacy or medication sourcing details
- Menopause/women's focus rather than weight-loss-only
Our Verdict
Both 1st Optimal and RegenCen score equally well overall — the right choice depends on your priorities.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose RegenCen if…
You want Women in MI or FL wanting GLP-1 weight loss alongside menopause and hormone care.
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Get started →1st Optimal vs RegenCen: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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