1st Optimal vs Queen RX
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Queen RX
Best for: budget-conscious patients seeking low-cost compounded GLP-1
Visit Queen RX →1st Optimal and Queen RX are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Queen RX starts at $100/mo, and Queen RX edges ahead overall (7.2 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Queen RX
$299 per quarter
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What’s included
1st Optimal
Inclusions not disclosed.
Queen RX
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Queen RX
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Queen RX |
|---|---|---|
| Starting Price | — | $100/mo |
| Features | ✓8 features | 4 features |
| States Available | Not disclosed | 45 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Queen RX
Queen RX offers compounded GLP-1 treatment (semaglutide, tirzepatide, liraglutide) at $299/quarter (~$100/mo). Available in 45 states (not KS, LA, MS, NM, WV).
Read our full Queen RX review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Queen RX
What we like
- $299/quarter (~$100/mo) — among the lowest GLP-1 pricing in the dataset
- Three GLP-1 options: semaglutide, tirzepatide, and liraglutide
- 45-state coverage
Watch-outs
- No LegitScript or PCAB accreditation
- No legal entity name or address disclosed
- No named pharmacy partners
- Not available in KS, LA, MS, NM, WV
Our Verdict
Queen RX edges out 1st Optimal with a higher overall score of 7.2/10 and is particularly strong for budget-conscious patients seeking low-cost compounded GLP-1. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Queen RX if…
You want budget-conscious patients seeking low-cost compounded GLP-1 and a starting price around $100/mo.
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Compounded GLP-1 alongside NAD+, peptide and longevity add-ons
From $197/mo
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Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →1st Optimal vs Queen RX: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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