1st Optimal vs Ozari Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Ozari Health
Best for: budget-focused patients wanting LegitScript-certified compounded GLP-1 from as low as $86/month
Visit Ozari Health →1st Optimal and Ozari Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Ozari Health starts at $86/mo, and Ozari Health edges ahead overall (7.3 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Ozari Health
From $86/mo; starts at $99, ranges to ~$348 by dose/plan; shipping included
From ~$149/mo; higher tiers by dose/plan (approximate)
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What’s included
1st Optimal
Inclusions not disclosed.
Ozari Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Ozari Health
7.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Ozari Health |
|---|---|---|
| Starting Price | — | $86/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Ozari Health
Ozari Health is a telehealth weight-loss platform offering physician-prescribed compounded GLP-1 from licensed pharmacies — semaglutide from $86/month and tirzepatide from around $149/month, with shipping included. Board-certified physicians review your online intake and prescribe if appropriate, and medications are compounded in 503A and 503B facilities. It's LegitScript certified and operated by Ozari LLC. The site publishes state-by-state pages but doesn't clearly list every state it serves or name its specific pharmacies.
Read our full Ozari Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Ozari Health
What we like
- Very low entry pricing — compounded semaglutide from $86/month
- LegitScript certified and operated by a named entity (Ozari LLC)
- Board-certified physicians; meds compounded in 503A and 503B facilities
- Shipping included in the plan price
Watch-outs
- Doesn't clearly list which states it serves or name its pharmacies
- Tirzepatide and higher semaglutide doses cost more than the $86 headline
- Compounded semaglutide and tirzepatide only — no brand-name options
- Newer, lighter web presence than established competitors
Our Verdict
Ozari Health edges out 1st Optimal with a higher overall score of 7.3/10 and is particularly strong for budget-focused patients wanting LegitScript-certified compounded GLP-1 from as low as $86/month. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Ozari Health if…
You want budget-focused patients wanting LegitScript-certified compounded GLP-1 from as low as $86/month and a starting price around $86/mo.
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Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →TrimRx
Best overall value
From $135/mo
Get started →Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →1st Optimal vs Ozari Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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