1st Optimal vs Omzo
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Omzo
Best for: Clinician-guided compounded GLP-1 with free delivery and FSA/HSA
Visit Omzo →1st Optimal and Omzo are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $179/mo, and Omzo edges ahead overall (6.9 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Omzo
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 500+ providers' prices on their own sites and email you when tracked prices move.
What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Omzo
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Omzo
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Omzo |
|---|---|---|
| Starting Price | ✓$99/mo | $179/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | — |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Omzo
Omzo is a multi-pillar telehealth service (weight loss, women's hormone health, sexual health, hair, skin, daily health) offering clinician-guided compounded GLP-1 — semaglutide and tirzepatide — with free discreet delivery and FSA/HSA eligibility. Medications are filled by an independent state-licensed compounding pharmacy. Pricing is not published on the marketing site (it appears after the intake quiz), and the company does not name its legal entity, pharmacy partner, or state-availability list.
Read our full Omzo review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Omzo
What we like
- Compounded GLP-1 (semaglutide and tirzepatide) with clinician guidance
- Free, discreet delivery on all treatments
- FSA/HSA eligible
- Multi-pillar: also women's hormone, sexual health, hair, skin, and daily health
Watch-outs
- Pricing not published on the site — shown only after the intake quiz
- Compounding pharmacy partner not named (states only 'independent state-licensed')
- States of operation not published
- Not LegitScript-certified (no certification displayed)
- Legal entity not named; governing law given only as 'the state in which Omzo operates'
Our Verdict
Omzo edges out 1st Optimal with a higher overall score of 6.9/10 and is particularly strong for Clinician-guided compounded GLP-1 with free delivery and FSA/HSA. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Omzo if…
You want Clinician-guided compounded GLP-1 with free delivery and FSA/HSA and a starting price around $179/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
DudeMeds
Men seeking no-fee GLP-1 access with oral and injectable options
From $175/mo
Get started →Oak
Compounded semaglutide and tirzepatide at a flat monthly price
From $133/mo
Get started →Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →1st Optimal vs Omzo: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and Omzo head-to-heads in the same category.
- 1st Optimal vs Amazon One Medical
- 1st Optimal vs Vytora Health
- 1st Optimal vs Collective
- Omzo vs CoreAge Rx
- Omzo vs EverSlim
- Omzo vs Found
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.