1st Optimal vs Novi
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programNovi
Best for transparent all-in compounded GLP-1 pricingStarting at $174/mo
Side-by-Side Comparison
| Feature | 1st Optimal | Novi |
|---|---|---|
| Overall Score | 6.7/10 | ✓8.6/10 |
| Starting Price | — | $174/mo |
| Editorial Rating | 3.4 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 5 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
Pros
- ✓Offers both semaglutide and tirzepatide with injectable and oral formats
- ✓Functional-medicine approach with at-home labs and blood-work interpretation
- ✓Unlimited coaching and ongoing support included
- ✓No long-term contracts
- ✓Board-certified doctors and nurse practitioners referenced
Cons
- ✗No public monthly pricing disclosed
- ✗No published state availability list
- ✗Compounded vs branded sourcing not clarified on site
- ✗Pricing only revealed after quiz or consultation
Novi
Pros
- ✓Transparent all-in monthly pricing — medication, clinician support, and shipping bundled with no hidden fees or membership add-ons
- ✓Both compounded semaglutide and tirzepatide available
- ✓Unlimited clinician messaging included at no extra cost
- ✓Free 2-day shipping on every refill
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro option
- ✗3-month minimum commitment is non-refundable per Terms of Service unless a clinician deems treatment medically inappropriate
- ✗State availability and pharmacy partners not publicly listed — patients learn during intake which states and pharmacies serve them
Our Verdict
Novi edges out 1st Optimal with a higher overall score of 8.6/10 and is particularly strong for transparent all-in compounded GLP-1 pricing. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.