1st Optimal vs NoBsRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →NoBsRx
Best for: fully published, flat-dose compounded GLP-1 pricing with the dispensing pharmacies named
Visit NoBsRx →1st Optimal and NoBsRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $140/mo, and NoBsRx edges ahead overall (7.6 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
NoBsRx
Pricing page: '$179/ monthly', flagged 'Popular'. Prepaid terms: 12 weeks $499, 24 weeks $999, 52 weeks $1,899. 'No dose-based price changes'.
Pricing page: '$199/ monthly'. Prepaid terms: 12 weeks $579, 24 weeks $1,149, 52 weeks $2,199. Oral dosage form not specified.
Pricing page: '$249/ monthly'. Prepaid terms: 12 weeks $649, 24 weeks $1,289, 52 weeks $2,599. 'No dose-based price changes'.
Pricing page 'Low-dose injectable semaglutide program': '$140/ monthly'; 12 weeks $409.
Pricing page 'Low-dose oral semaglutide program': '$179/ monthly'; 12 weeks $409.
Pricing page 'Low-dose injectable tirzepatide program': '$140/ monthly'; 12 weeks $409.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
NoBsRx
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
NoBsRx
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | NoBsRx |
|---|---|---|
| Starting Price | ✓$99/mo | $140/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About NoBsRx
NoBsRx is a telehealth platform that connects you with licensed providers for compounded GLP-1 treatment, filled by state-licensed 503A pharmacies it names in its terms. Every program price is posted before you start: injectable semaglutide $179/mo, oral semaglutide $199/mo and injectable tirzepatide $249/mo, with low-dose programs from $140/mo and no price change as your dose rises. Prepaid 12-, 24- and 52-week terms cost less per month.
Read our full NoBsRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
NoBsRx
What we like
- Every program price is posted before intake with no email wall: semaglutide from $179/mo, tirzepatide $249/mo
- Same price at every dose: each program card reads 'No dose-based price changes'
- Low-dose injectable semaglutide or tirzepatide at $140/mo, plus an oral semaglutide option
- Its terms name the four state-licensed pharmacies that may fill your prescription, with addresses and phone numbers
- LegitScript seal is served from LegitScript's own image server, not self-hosted
- Publishes a support phone number and email, with email replies promised within 1–2 business days
- States plainly that its compounded semaglutide and tirzepatide are not FDA-approved
Watch-outs
- No company legal name, business address or governing state is published anywhere on the site
- The prescribing medical group is not named; the site says only that independent licensed providers review your intake
- Plans are labeled monthly, but the intake's cancellation policy says charges run every 28 days: 13 charges a year, not 12
- Its subscription terms say medication, dispensing and shipping fees are outside the platform fee, at odds with 'what's published is what you pay'
- Cancellation instructions conflict: NoBsRx says email support (no self-service), the intake's policy says use the patient portal
- Platform fees are non-refundable once a clinical review starts, even if you are found ineligible
- State availability is not published; the site says programs are not available in all states
- Compounded semaglutide and tirzepatide are not FDA-approved
Our Verdict
NoBsRx edges out 1st Optimal with a higher overall score of 7.6/10 and is particularly strong for fully published, flat-dose compounded GLP-1 pricing with the dispensing pharmacies named. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose NoBsRx if…
You want fully published, flat-dose compounded GLP-1 pricing with the dispensing pharmacies named and a starting price around $140/mo.
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Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →TrimRx
Best overall value
From $149/mo
Get started →1st Optimal vs NoBsRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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