1st Optimal vs MultiMedRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
MultiMedRx
Best for: brand-name GLP-1s plus broader cardiometabolic care under one entity
Visit MultiMedRx →1st Optimal and MultiMedRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $100/mo, and MultiMedRx edges ahead overall (6.9 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
MultiMedRx
ADDED 2026-08-15 with a deliberate caveat: $100 is NOT a medication price. It is MultiMedRx's entire published cost — 'Pay the $100 fully refundable consultation fee and consult with a medical healthcare provider'. What the visit buys is listed as 'Provider consultation, GLP-1 prescription, Insurance coverage paperwork, Phone support'. The medication itself is filled and billed elsewhere and is not priced on this site.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
MultiMedRx
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
MultiMedRx
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | MultiMedRx |
|---|---|---|
| Starting Price | ✓$99/mo | $100/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | — |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About MultiMedRx
MultiMedRx is a LegitScript-certified telehealth platform with physical offices in Newport Beach, CA and Reno, NV. It stands out by prominently featuring brand-name GLP-1s — Ozempic, Wegovy, and Zepbound — alongside a broader cardiometabolic menu including metformin, testosterone, and HRT, rather than the compounded-only model most peers use. Access starts with a $100 fully refundable consultation fee; medication pricing is shown after intake.
Read our full MultiMedRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
MultiMedRx
What we like
- Legal entity disclosed (MMRX MultiMedRx LLC) — uncommon transparency
- Two physical addresses listed: Newport Beach, CA and Reno, NV
- LegitScript seal present
- Features brand-name GLP-1s (Ozempic, Wegovy, Zepbound) — rare in a mostly compounded-only field
- Broader cardiometabolic menu (metformin, testosterone, HRT) alongside GLP-1
- $100 consultation fee is fully refundable
Watch-outs
- No Mounjaro or Foundayo in the brand-name lineup (only Ozempic, Wegovy, Zepbound)
- Monthly GLP-1 pricing isn't published — gated behind the consultation
- $100 consultation fee adds friction; many peers bundle it into the medication price
- Per-state availability not listed; only CA and NV offices disclosed
- Whether compounded GLP-1 is offered isn't clear — verify during intake
- Partner pharmacy not disclosed
- State of incorporation not disclosed
Our Verdict
MultiMedRx edges out 1st Optimal with a higher overall score of 6.9/10 and is particularly strong for brand-name GLP-1s plus broader cardiometabolic care under one entity. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose MultiMedRx if…
You want brand-name GLP-1s plus broader cardiometabolic care under one entity and a starting price around $100/mo.
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Sesame Care
Brand-name GLP-1s at cash prices, no compounding
From $25/mo
Get started →Try Ageless
Lowest-tier compounded GLP-1 in injection, troche and sublingual forms
From $119/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $88/mo
Get started →1st Optimal vs MultiMedRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.