1st Optimal vs Good Girl Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Good Girl Rx
Best for: patients seeking multiple compounded GLP-1 formats with pharmacy quality standards
Visit Good Girl Rx →1st Optimal and Good Girl Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Good Girl Rx starts at $79/mo, and Good Girl Rx edges ahead overall (7.2 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Good Girl Rx
From $134/mo on annual plan (monthly $179, quarterly $159; all paid upfront).
Semaglutide microdose, from $79/mo.
Oral dissolving tablets, from $214/mo.
From $235/mo.
Tirzepatide microdose, from $139/mo.
Tirzepatide pills, from $291/mo.
From $1,580/mo; limited availability.
From $1,991/mo; limited availability.
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What’s included
1st Optimal
Inclusions not disclosed.
Good Girl Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Good Girl Rx
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Good Girl Rx |
|---|---|---|
| Starting Price | — | $79/mo |
| Features | ✓8 features | 7 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Good Girl Rx
Good Girl Rx (Good Girl LLC) offers compounded semaglutide and tirzepatide in injectable, microdose, and oral dissolving tablet (ODT) formats. Brand-name Ozempic, Wegovy, Zepbound, Mounjaro also listed (limited availability). LegitScript certified. Dispensed by licensed 503A/503B pharmacies. Founded by Savannah Chrisley.
Read our full Good Girl Rx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Good Girl Rx
What we like
- LegitScript certified
- Multiple formats — injectable, microdose, and ODT pills — for both semaglutide and tirzepatide
- Dispensed by licensed 503A or 503B pharmacies
- Limited brand-name options available (Ozempic, Wegovy, Zepbound, Mounjaro)
- Named legal entity with a Nashville address
- Financing via Affirm, Klarna, and Afterpay
Watch-outs
- State availability not disclosed
- Very new brand — founded January 2025
- Celebrity-founded (Savannah Chrisley) — brand vs clinical credibility
Our Verdict
Good Girl Rx edges out 1st Optimal with a higher overall score of 7.2/10 and is particularly strong for patients seeking multiple compounded GLP-1 formats with pharmacy quality standards. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Good Girl Rx if…
You want patients seeking multiple compounded GLP-1 formats with pharmacy quality standards and a starting price around $79/mo.
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Get started →1st Optimal vs Good Girl Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.