1st Optimal vs Fresh Day Meds
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Fresh Day Meds
Best for: lowest-cost compounded GLP-1 from a LegitScript-certified Texas platform
Visit Fresh Day Meds →1st Optimal and Fresh Day Meds are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Fresh Day Meds starts at $133/mo, and Fresh Day Meds edges ahead overall (7.8 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Fresh Day Meds
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What’s included
1st Optimal
Inclusions not disclosed.
Fresh Day Meds
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Fresh Day Meds
7.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Fresh Day Meds |
|---|---|---|
| Starting Price | — | $133/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Fresh Day Meds
Fresh Day Meds is a Houston-based, LegitScript-certified telehealth platform offering compounded semaglutide and tirzepatide alongside hair, sexual-wellness, testosterone, and daily-wellness products on one account. It bundles the consultation fee into the medication price and ships free with prescription review in under four hours. Among the lowest in the segment — semaglutide from $133/mo and tirzepatide from $166/mo on the 3-month plan.
Read our full Fresh Day Meds review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Fresh Day Meds
What we like
- Among the lowest compounded GLP-1 pricing in the market ($133/mo sema, $166/mo tirz on 3-month bundle)
- LegitScript certified and HIPAA compliant
- Coverage across 49 states plus DC
- Free expedited shipping with prescription review in under 4 hours
- No membership or consultation fees on top of medication price
- Single account covers GLP-1, hair, sexual wellness, TRT, and NAD+/B12
- Houston, TX headquarters publicly disclosed
Watch-outs
- Compounding pharmacy partner not named — only 503A/503B facilities referenced
- Medical director and founder names not disclosed
- Compounded-only — no brand-name fallback if the FDA shortage pathway ends
- State count is inconsistent: ToS lists 49 states + DC (no Arkansas) while About page claims all 50 + DC
- Dose-specific pricing not shown — only flat 'as low as' pricing before checkout
- Medical group operates as Telegra MD LLC (Spokane, WA) — a typical white-label arrangement
Our Verdict
Fresh Day Meds edges out 1st Optimal with a higher overall score of 7.8/10 and is particularly strong for lowest-cost compounded GLP-1 from a LegitScript-certified Texas platform. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Fresh Day Meds if…
You want lowest-cost compounded GLP-1 from a LegitScript-certified Texas platform and a starting price around $133/mo.
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Get started →1st Optimal vs Fresh Day Meds: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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