1st Optimal vs Blis MD
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →Blis MD
Best for: people who want transparent flat-price compounded semaglutide or tirzepatide with provider check-ins
Visit Blis MD →1st Optimal and Blis MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Blis MD starts at $139/mo, and Blis MD edges ahead overall (7.0 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Blis MD
Flat monthly; includes medication and provider check-ins
Flat monthly; includes bi-weekly check-ins
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What’s included
1st Optimal
Inclusions not disclosed.
Blis MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Blis MD
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Blis MD |
|---|---|---|
| Starting Price | — | $139/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Blis MD
Blis MD is a US telehealth offering personalized GLP-1 weight-loss treatment with compounded semaglutide and tirzepatide, prescribed after a free virtual consultation with a licensed provider. Pricing is transparent and flat: semaglutide is 139 dollars per month and tirzepatide is 199 dollars per month, each including a monthly medication supply, personalized dosing, and provider check-ins. Blis MD also markets other wellness peptides such as BPC-157, NAD plus, and Sermorelin. Compounded medications are not FDA-approved. Contact is by phone and email; specific states served are not published.
Read our full Blis MD review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Blis MD
What we like
- Transparent flat monthly pricing published upfront (139 dollars semaglutide, 199 dollars tirzepatide)
- Free initial virtual consultation with a licensed provider
- Both semaglutide and tirzepatide offered with ongoing provider check-ins
Watch-outs
- Compounding pharmacy is not named publicly
- States served are not listed on the site
- Thin public trust signals (no LegitScript seal or named medical director found)
Our Verdict
Blis MD edges out 1st Optimal with a higher overall score of 7.0/10 and is particularly strong for people who want transparent flat-price compounded semaglutide or tirzepatide with provider check-ins. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Blis MD if…
You want people who want transparent flat-price compounded semaglutide or tirzepatide with provider check-ins and a starting price around $139/mo.
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Direct Meds
Listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering
From $249/mo
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From $199.99/mo
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Brand-name GLP-1s (Wegovy, Zepbound) at LillyDirect/NovoCare cash prices — no compounding
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Get started →1st Optimal vs Blis MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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