1st Optimal vs Big Easy Weight Loss
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →Big Easy Weight Loss
Best for: budget shoppers wanting low-cost compounded glp-1 nationwide
Visit Big Easy Weight Loss →1st Optimal and Big Easy Weight Loss are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $165/mo, and Big Easy Weight Loss edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Big Easy Weight Loss
Sold only in 12-week packages: 'Semaglutide Compounded Treatment — Starting at $495 for 12 weeks', discounted to $399 for new patients. $495 over 12 weeks is $165 a calendar month; the starter price works out at $133.
'Tirzepatide Compounded Treatment — Starting at $599 for 12 weeks', discounted to $499 for new patients — $199.67 and $166 a calendar month respectively.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Big Easy Weight Loss
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Big Easy Weight Loss
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Big Easy Weight Loss |
|---|---|---|
| Starting Price | ✓$99/mo | $165/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 51 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Big Easy Weight Loss
Big Easy Weight Loss (joinbigeasy.com) is a New Orleans MD-run telehealth that ships compounded GLP-1 medication nationwide. The site states it serves all 50 states. Compounded semaglutide starts at 399 dollars for a 12-week supply (about 133 dollars per month) and compounded tirzepatide at 499 dollars for 12 weeks (about 166 dollars per month), billed as multi-week packages. Prescriptions are filled through named partner pharmacies including Seven Cells, Hallandale, OptioRx and Miller's. Chief Medical Officer is Dr. Gabriel Lasala; support by phone and email.
Read our full Big Easy Weight Loss review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Big Easy Weight Loss
What we like
- Low pricing: about 133 dollars per month for semaglutide, 166 for tirzepatide
- Site states it serves all 50 states with a 2 to 3 day pharmacy turnaround
- Names its partner compounding pharmacies and a Chief Medical Officer
Watch-outs
- Priced as 10 to 12-week packages rather than a simple monthly fee
- New-patient pricing is promotional and may rise on renewal
Our Verdict
Big Easy Weight Loss edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for budget shoppers wanting low-cost compounded glp-1 nationwide. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Big Easy Weight Loss if…
You want budget shoppers wanting low-cost compounded glp-1 nationwide and a starting price around $165/mo.
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bmiMD
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →RxSpan MD
Physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →1st Optimal vs Big Easy Weight Loss: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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