1st Optimal vs AZ Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
AZ Health
Best for: flat-rate compounded GLP-1 with no insurance and free shipping
Visit AZ Health →1st Optimal and AZ Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $179/mo, and AZ Health edges ahead overall (7.2 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
AZ Health
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
AZ Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
AZ Health
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | AZ Health |
|---|---|---|
| Starting Price | ✓$99/mo | $179/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About AZ Health
AZ Health (AZHM) is an Arizona-based, 100% virtual medical weight-loss clinic offering physician-prescribed compounded semaglutide (from $179/mo) and tirzepatide (from $199/mo), plus NAD+ injections, on flat monthly pricing with no insurance required. It is FSA/HSA eligible with free discreet shipping and cancel-anytime. The site discloses that compounded medications are not FDA-approved and require a prescription. It is a single-page site with no published Terms/Privacy, and its LegitScript certification is self-stated and not independently verifiable.
Read our full AZ Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
AZ Health
What we like
- Transparent flat monthly pricing — semaglutide from $179/mo, tirzepatide from $199/mo, no insurance required
- Discloses that compounded medications are not FDA-approved and require a prescription
- FSA/HSA eligible, free discreet shipping, and cancel anytime
- Ongoing physician check-ins; also offers NAD+ injections
Watch-outs
- LegitScript certification is self-stated on the site and not independently verifiable
- Single-page site with no published Terms, Privacy, or HIPAA policy
- Compounding pharmacy partner not named (states only 'FDA-registered pharmacies')
- Legal entity not disclosed; availability limited (~half of US states, Arizona-focused)
Our Verdict
AZ Health edges out 1st Optimal with a higher overall score of 7.2/10 and is particularly strong for flat-rate compounded GLP-1 with no insurance and free shipping. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose AZ Health if…
You want flat-rate compounded GLP-1 with no insurance and free shipping and a starting price around $179/mo.
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Willow
Mainstream telehealth GLP-1 access
From $299/mo
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Men's weight loss
From $165/mo
Get started →SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →1st Optimal vs AZ Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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