1st Optimal vs Avono Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Avono Health
Best for: shoppers who want a wide, transparently priced compounded GLP-1 menu including microdose and oral options
Visit Avono Health →1st Optimal and Avono Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Avono Health starts at $179/mo, and Avono Health edges ahead overall (7.2 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Avono Health
Injection (microdose).
Oral dissolving tablets (microdose).
Injection (microdose).
Oral dissolving tablets (microdose).
Injection. Bundle discounts at 3/6/12 months.
Oral capsules.
Injection. Bundle discounts at 3/6/12 months.
Oral capsules.
What’s included
1st Optimal
Inclusions not disclosed.
Avono Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Avono Health
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Avono Health |
|---|---|---|
| Starting Price | — | $179/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Avono Health
Fully online compounded GLP-1 telehealth with transparent, tiered pricing — microdose and standard semaglutide and tirzepatide in both injection and oral forms — plus US-licensed clinicians, 24/7 messaging support, and free discreet shipping.
Read our full Avono Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Avono Health
What we like
- Transparent tiered pricing from $179/mo (microdose semaglutide injection)
- Full compounded range — semaglutide and tirzepatide, injection and oral, microdose and standard
- Free and discreet shipping; 24/7/365 messaging support; 100% online
- US-licensed clinicians and pharmacies; bundle discounts at 3/6/12 months
Watch-outs
- Medications are compounded, not FDA-approved brand-name
- Compounding pharmacy not publicly named
- State availability not published
- Newer brand with limited independent review history
Our Verdict
Avono Health edges out 1st Optimal with a higher overall score of 7.2/10 and is particularly strong for shoppers who want a wide, transparently priced compounded GLP-1 menu including microdose and oral options. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Avono Health if…
You want shoppers who want a wide, transparently priced compounded GLP-1 menu including microdose and oral options and a starting price around $179/mo.
Ready to start? Vetted GLP-1 providers
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Gala
Compounded GLP-1/GIP combo therapy on a yearly subscription with free shipping nationwide
From $149/mo
Get started →Trimi Health
Budget-conscious shoppers
From $99/mo
Get started →Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $49/mo
Get started →1st Optimal vs Avono Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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