Bupropion

Definition

A dopamine and norepinephrine reuptake inhibitor used as an antidepressant (Wellbutrin), smoking-cessation aid (Zyban), and the active half of Contrave. Modest single-agent weight-loss effect (~2-3 kg). Carries a boxed warning for suicidal behavior in young adults. Contraindicated in seizure disorders and active eating disorders.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

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