ZYP Medical vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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ZYP Medical
Best for Men in NE, IA, SD, KS, CO, or AZ wanting low-cost compounded GLP-1s with oral optionStarting at $150/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | ZYP Medical | Enhance MD |
|---|---|---|
| Overall Score | 7.0/10 | ✓8.6/10 |
| Starting Price | $150/mo | ✓$49/mo |
| Editorial Rating | 3.5 ★ /5 | ✓4.3 ★ /5 |
| Features | 6 features | 6 features |
| States Available | 6 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
ZYP Medical
Pros
- ✓Transparent flat-rate pricing including medication and shipping with no hidden fees
- ✓Low $50 initial one-hour consultation
- ✓Offers both injectable and oral tirzepatide options
- ✓No membership fees and pricing decreases as treatment progresses
- ✓Care from a board-certified family nurse practitioner
- ✓Discreet 2-day shipping
Cons
- ✗Compounded medications are not FDA-approved
- ✗Available in only six states (NE, IA, SD, KS, CO, AZ)
- ✗Cash-pay only; no insurance noted
- ✗No named compounding pharmacy partner disclosed
- ✗No LegitScript certification shown on site
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out ZYP Medical with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. ZYP Medical remains a solid alternative, especially if you're looking for Men in NE, IA, SD, KS, CO, or AZ wanting low-cost compounded GLP-1s with oral option.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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