Trillium Meds vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Trillium Meds
Best for: LegitScript-certified compounded GLP-1 telehealth, all 50 states + PR; sema $119/mo, tirz $199/mo (3-mo)
Visit Trillium Meds →
Enhance MD
Best for: lab-monitored compounded GLP-1 with mandatory video visit
Visit Enhance MD →Trillium Meds and Enhance MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Trillium Meds starts lower at $119/mo versus $212/mo, and Enhance MD edges ahead overall (8.6 vs 7.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Trillium Meds
Verbatim site meta: 'pricing from $109.' 3-month plan at $119/mo ($357 total); 1-month plan at $159/mo. All-inclusive price covers compounded semaglutide (with B6, dispensed by BPI Labs or ProRx pharmacy), provider consultation, and shipping. No additional fees.
3-month plan at $199/mo ($599 total); 1-month plan at $249/mo. All-inclusive price covers compounded tirzepatide (with B6, dispensed by BPI Labs or ProRx pharmacy), provider consultation, and shipping. No additional fees.
Enhance MD
What’s included
Trillium Meds
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Billed separately
Enhance MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Included
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Trillium Meds
7.2/10
Enhance MD
8.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Trillium Meds | Enhance MD |
|---|---|---|
| Starting Price | ✓$119/mo | $212/mo |
| Features | ✓8 features | 6 features |
| States Available | ✓52 | 39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Trillium Meds
Trillium Meds is a small, owner-operated telehealth platform based in Portland, OR that connects patients with independent licensed providers and FDA-registered compounding pharmacies for compounded semaglutide and tirzepatide. Pricing is all-inclusive—covering medication, provider consultation, and shipping—with no membership fees and flexible 1-month, 3-month fixed-dose, or 3-month titrated programs. LegitScript certified and available in all 50 states plus Puerto Rico.
Read our full Trillium Meds review →About Enhance MD
Enhance MD pairs compounded semaglutide and tirzepatide with mandatory baseline metabolic labs at Quest Diagnostics and a synchronous video visit with a board-certified clinician — a more rigorous onboarding than the async-only compounded GLP-1 model most telehealth providers use. Three tiers (Core semaglutide, Advanced tirzepatide, Elite combined) plus aggressive intro pricing ($49 first month on Core).
Read our full Enhance MD review →Pros & Cons
Trillium Meds
What we like
- LegitScript certified with an active seal; serves all 50 states plus Puerto Rico with no geographic restrictions
- All-inclusive pricing covers medication, provider consultation, and shipping with no hidden fees or add-ons
- Two pharmacy options (BPI Labs with B6, ProRx) and three plan structures: 1-month, 3-month fixed, or 3-month titrated
- Small owner-operated; founder personally handles customer support outside business hours for direct, responsive service
- Klarna and Affirm financing available; pause anytime with no long-term commitment required
Watch-outs
- No labs, coaching, or clinical monitoring included — telehealth Rx and pharmacy fulfillment only
- Small single-operator platform may limit capacity and support consistency as patient volume grows
- Compounded medications are not FDA-approved; newer platform with limited long-term public track record
- Tirzepatide from $199/mo (3-mo plan) is mid-market; sema from $119/mo competitive but not lowest available
- No live video consult disclosed; async intake-form-based provider review by external licensed provider network
Enhance MD
What we like
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- Unlimited clinician messaging and dose-adjustment support included
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- No insurance accepted — cash pay, HSA/FSA eligible
- Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Trillium Meds with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Trillium Meds remains a solid alternative, especially if you're looking for LegitScript-certified compounded GLP-1 telehealth, all 50 states + PR; sema $119/mo, tirz $199/mo (3-mo).
Choose Trillium Meds if…
You want LegitScript-certified compounded GLP-1 telehealth, all 50 states + PR; sema $119/mo, tirz $199/mo (3-mo) and a starting price around $119/mo.
Choose Enhance MD if…
You want lab-monitored compounded GLP-1 with mandatory video visit and a starting price around $212/mo.
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Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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